Transcriptional regulation of gene expression: Dietary sialic acid interaction in brain cognitive development

基因表达的转录调控：饮食唾液酸在大脑认知发展中的相互作用

• 批准号: nhmrc : 512488
• 负责人: A/Pr Bing Yu
• 金额: $ 3.11万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptional-regulation-gene-cognitive-development/77217
• 关键词: Transcriptional; regulation; gene; expression; Dietary

In 2004, 8.2% of Australian live births were preterm with poor long-term cognitive outcomes. Sialic acid (SA), a key component of both human milk oligosaccharides and neural tissues, plays a role in neuronal development. This study will examine the mechanisms of how dietary SA or active learning interacts with genes during brain development. It will benefit the neonatal care of all children, particularly those born premature and ultimately, the quality of life of many Australians.

2004年，8.2%的澳大利亚活产婴儿是早产儿，长期认知结果较差。唾液酸（SA）是人乳低聚糖和神经组织的关键组分，在神经元发育中起作用。本研究将探讨饮食SA或主动学习在大脑发育过程中如何与基因相互作用的机制。这将有利于所有儿童的新生儿护理，特别是早产儿，并最终提高许多澳大利亚人的生活质量。