Transcriptome landscape of brown/beige adipogenesis in humans

人类棕色/米色脂肪生成的转录组景观

• 批准号: nhmrc : 1088123
• 负责人: Dr Paul Lee
• 金额: $ 26.23万
• 依托单位: Garvan Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/transcriptome-landscape-brownbeige-adipogenesis-humans/519196
• 关键词: Transcriptome; landscape; brown; beige; adipogenesis

There are three kinds of fat in the body: white, brown and beige. While excess white fat results in obesity, brown fat is associated with leanness and lowers blood glucose levels. Recent animal experiments show that under certain conditions, white fat can be transformed into beige fat, leading to benefits such as weight loss. The current project grant involves examination of human fat cells grown in the laboratory and investigation on the genetics of brown and beige fat.

人体内有三种脂肪：白色、棕色和米色。虽然过量的白色脂肪会导致肥胖，但棕色脂肪与苗条有关，并会降低血糖水平。最近的动物实验表明，在一定条件下，白色脂肪可以转化为米色脂肪，从而产生减肥等好处。目前的项目拨款包括检查实验室中培养的人类脂肪细胞，以及调查棕色和米色脂肪的遗传学。