Therapeutic Potential of Brown Fat in Humans

棕色脂肪可以保护动物免受肥胖和糖尿病的侵害。拥有丰富棕色脂肪的人在新陈代谢方面是健康的。发现促进棕色脂肪功能的药物可能会导致代谢紊乱的新疗法。这项提案将研究这种药物的作用，它是以棕色脂肪释放的一种因子(称为FGF21)为模型的。该项目还将寻找人类棕色脂肪释放的其他因素，这些因素可能成为未来肥胖治疗的目标。

Brown fat protects animals against obesity and diabetes. Humans with abundant brown fat are metabolically healthy. Identification of medication that boosts brown fat function may lead to novel treatment of metabolic disorders. This proposal will examine the role of such a medication, which is modeled on a factor (called FGF21) released from brown fat. The project will also search for other factors released by human brown fat, which may become future targets of obesity treatment.