Maximizing fMRI results for the study of executive functioning by combining BOLD and ASL methods

记忆不是单一的，而是一个多方面的认知过程，需要多个大脑区域和回路。大脑如何存储新的事件，并将它们整合到现有的知识体系中，最终使这些事件可以访问，以影响后续的学习和记忆，这是拟议的研究计划的重点。更具体地说，一种结合动脉自旋标记(ASL)和血氧水平依赖(BOLD)效应的功能磁共振成像(FMRI)创新方法将被实施和优化，以阐明这一复杂认知过程的神经关联。利用这种ASL/BOLD功能磁共振成像技术，将系统地研究不同时间跨度(远距离、近期)上的几种类型的长期记忆(语义、情景、空间)的功能和结构特性，同时考虑编码(情绪、事实)的背景和随着时间发生的记忆的转换(细节、生动)。

Memory is not unitary but rather a multifaceted cognitive process requiring a multiplicity of brain regions and circuitry. How the brain stores new events and integrates them into the existing body of knowledge and eventually making the events accessible to influence subsequent learning and memory is the focus of the proposed research program. More specifically, an innovative method of functional magnetic resonance imaging (fMRI), using a combination of arterial spin labelling (ASL) and the blood oxygen level dependent (BOLD) effect, will be implemented and optimized to elucidate the neural correlates of this complex set of cognitive processes. Using this ASL/BOLD fMRI technique, the functional and structural properties of several types of long-term memory (semantic, episodic, spatial) over different time spans (remote, recent), taking into consideration the context of the encoding (emotional, factual) and the transformation of memories that occurs over time (details, vividness), will be systematically investigated.