Translating molecular determinants of advanced glaucoma to personalise risk profiling in early disease.

转化晚期青光眼的分子决定因素以个性化早期疾病的风险分析。

• 批准号: nhmrc : GNT1154824
• 负责人: Prof Jamie Craig
• 金额: $ 58.53万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Practitioner Fellowships
• 财政年份: 2019
• 资助国家: 澳大利亚
• 起止时间: 2019-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/translating-molecular-determinants-early-disease/1349158
• 关键词: Translating; molecular; determinants; advanced; glaucoma

Glaucoma is a highly heritable complex disease and the leading cause of irreversible blindness worldwide. We used genetic techniques on a disease registry of individuals with glaucoma blindness to define risk factors associated with poor visual outcomes. The knowledge obtained from defining these risk factors will be used in a prospective longitudinal study to determine whether we can predict if individuals suspected of having glaucoma (glaucoma suspects) will progress to manifest vision loss.

青光眼是一种高度遗传的复杂疾病，是全球范围内不可逆性失明的主要原因。我们使用遗传技术对青光眼失明患者进行疾病登记，以确定与视力不良相关的风险因素。从定义这些风险因素中获得的知识将用于前瞻性纵向研究，以确定我们是否可以预测疑似青光眼患者（青光眼疑似患者）是否会进展为视力丧失。