Translating molecular determinants of advanced glaucoma to personalise risk profiling in early disease.

青光眼是一种高度遗传性的复杂疾病，是世界范围内导致不可逆转失明的主要原因。我们使用基因技术对青光眼失明患者的疾病登记，以确定与视力不良结果相关的风险因素。通过定义这些危险因素获得的知识将被用于一项前瞻性的纵向研究，以确定我们是否可以预测疑似患有青光眼的人是否会进展为明显的视力丧失。

Glaucoma is a highly heritable complex disease and the leading cause of irreversible blindness worldwide. We used genetic techniques on a disease registry of individuals with glaucoma blindness to define risk factors associated with poor visual outcomes. The knowledge obtained from defining these risk factors will be used in a prospective longitudinal study to determine whether we can predict if individuals suspected of having glaucoma (glaucoma suspects) will progress to manifest vision loss.