Effects of cortical arousal changes due to sleepiness, alcohol & coffeine on EEG/ERP measures of performance and brain function

困倦、酒精对皮质唤醒变化的影响

• 批准号: 341576-2008
• 负责人: Murphy, Timothy
• 金额: $ 1.09万
• 依托单位: Brock University
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=429730
• 关键词: Effects; cortical; arousal; changes; due

This research will examine the effects of several challenges to everyday functioning such as sleepiness, mild intoxication and reaction to risk. Behavioural performance and brain activity will be assessed under conditions of sleep deprivation, alcohol consumption and during a gambling (risky) situtation. In addition, caffeine, a common countermeasure taken to reverse the effects of sleepiness and intoxication will be examined. I will test individuals before and after ingesting enough alcohol to raise their blood alcohol to approximately .04 (half the legal limit to drive in many provinces) and/or after approximately 20 hours of wakefulness. I will assess their performance on a variety of tasks while also collecting EEG data (brain electrocortical activity). I will also test the effectiveness (behaviourally and in terms of EEG) of a common countermeasure, caffeine. The individuals in my experiments will receive the equivalent of approximately 2 cups of coffee before being retested to determine if their performance improves, or their brain activity returns to normal levels.

这项研究将检查日常功能的几个挑战的影响，如嗜睡，轻度中毒和对风险的反应。行为表现和大脑活动将在睡眠剥夺、饮酒和赌博（风险）情况下进行评估。此外，咖啡因，一种常见的对策，采取扭转嗜睡和中毒的影响将被检查。我将在摄入足够的酒精以将血液酒精含量提高到大约0.04（许多省份驾驶法律的限制的一半）之前和/或大约20小时清醒之后对个人进行测试。我将评估他们在各种任务上的表现，同时收集EEG数据（大脑皮层电活动）。我还将测试一种常见的对策咖啡因的有效性（行为和脑电图方面）。在我的实验中，参与者将接受相当于大约2杯咖啡的咖啡，然后重新测试，以确定他们的表现是否有所改善，或者他们的大脑活动是否恢复到正常水平。