New enantioselective catalytic synthesis of alcohols, carboxylic acids, and heterocycles

醇、羧酸和杂环的新型对映选择性催化合成

• 批准号: 342375-2007
• 负责人: Dong, Vy
• 金额: $ 3.06万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2009
• 资助国家: 加拿大
• 起止时间: 2009-01-01 至 2010-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=430089
• 关键词: New; enantioselective; catalytic; synthesis; alcohols

Research in organic chemistry is a fundamental and central endeavor that impacts the many fields of science which require the design and synthesis of molecules. The advent of powerful synthetic methods will dramatically enhance our capability to discover life-saving therapeutics, invent materials with useful and unusual properties, as well as investigate biology at the molecular level. In the chemistry department at the University of Toronto, the Dong Research Group is engaged in developing innovative strategies to address modern challenges in organic synthesis. Our main approach involves harnessing the unique reactivity of transition metal-complexes to transform readily available materials into useful organic products. Some of our long-term goals include finding new ways to functionalize carbon-hydrogen bonds, used carbon-dioxide as a raw material, and construct nitrogen-containing heterocycles. Importantly, we plan to produce methods which are more selective, more efficient, and environmentally friendly compared to the state-of-the-art. Aside from the practical significance, our studies are expected to result in fundamentally interesting and novel chemical reactivity. Ultimately, we will engage in understanding the mechanism of action for these transforms, as well as applying them to make molecules of interest to natural product synthesis, materials science, and chemical biology. The graduate students and postdoctoral research fellows in our group will be trained in the art of organic synthesis and acquire the skills needed to be tomorrow's innovators in academia and the pharmaceutical and fine chemical industry.

有机化学研究是一项基础性的核心工作，影响着需要分子设计和合成的许多科学领域。 强大的合成方法的出现将极大地增强我们发现拯救生命的疗法、发明具有有用和不寻常特性的材料以及在分子水平上研究生物学的能力。 在多伦多大学化学系，董研究小组致力于开发创新策略，以应对现代有机合成的挑战。 我们的主要方法涉及利用过渡金属配合物的独特反应性将现成的材料转化为有用的有机产品。 我们的一些长期目标包括寻找新的方法来功能化碳氢键、使用二氧化碳作为原材料以及构建含氮杂环。 重要的是，我们计划生产比最先进的方法更具选择性、更高效、更环保的方法。 除了实际意义之外，我们的研究预计将产生根本上有趣且新颖的化学反应性。 最终，我们将致力于了解这些转变的作用机制，并应用它们来制造天然产物合成、材料科学和化学生物学感兴趣的分子。 我们小组的研究生和博士后研究员将接受有机合成艺术的培训，并获得成为学术界以及制药和精细化工行业未来创新者所需的技能。