A glovebox for discovery of new metal-catalyzed methods

用于发现新金属催化方法的手套箱

• 批准号: 344923-2007
• 负责人: Dong, Vy
• 金额: $ 4.38万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=325885
• 关键词: glovebox; discovery; new; metal; catalyzed

Our research program is motivated by the need for synthetic methods that are more efficient, selective, and environmentally sustainable.  Towards this challenge, we plan to develop innovative ways to functionalize carbon-hydrogen bonds, use carbon dioxide as a raw material, and build nitrogen-containing heterocycles. While these important goals are diverse, our research strategy maintains an essential theme: the discovery of new transition metal-catalysts to rapidly transform readily available reagents into valuable organic products. Transition metal complexes have an amazing ability to make, break, and rearrange bonds within an organic molecule via mechanisms which cannot be accessed using more traditional catalysts (e.g. protic or Lewis acids).  However, many reactive metal-complexes (and their corresponding ligands) are also highly sensitive to oxygen and moisture.  Because manipulation of these air and moisture sensitive species is critical to our proposed research, we are requesting an inert atmosphere dry box or 'glovebox'.  The requested equipment will enable the synthesis, characterization, and application of various ligands and metal-complexes under an inert atmosphere. This technology will enable the discovery of transformations, catalysts, and reagents which would be impossible to discover under normal atmospheric conditions.  In addition, the researchers involved in this program will be trained in the most advanced techniques of modern organic chemistry and develop the necessary skills to perform air and moisture sensitive transformations.     The equipment proposal to be supported will ultimately lead to the discovery of fundamentally new chemical reactivity and enhance our ability to make molecules of interest to many fields of research.

我们的研究计划是出于对更高效，选择性和环境可持续性的合成方法的需求。为了应对这一挑战，我们计划开发碳-氢键功能化的创新方法，使用二氧化碳作为原料，并构建含氮杂环。虽然这些重要的目标是不同的，我们的研究策略保持一个基本的主题：新的过渡金属催化剂的发现，以迅速转化为有价值的有机产品现成的试剂。过渡金属配合物具有惊人的能力，可以通过使用更传统的催化剂无法获得的机制在有机分子中形成，断裂和重排键（例如质子酸或刘易斯酸）。（及其相应的配体）对氧气和水分也高度敏感。因为这些空气和水分敏感物质的操作对我们提出的研究至关重要，我们需要一个惰性气氛干燥箱或“手套箱”。所需设备将能够在惰性气氛下合成、表征和应用各种配体和金属络合物。该技术将使人们能够发现在正常大气条件下不可能发现的转化、催化剂和试剂。此外，参与该计划的研究人员将接受现代有机化学最先进技术的培训，并培养必要的技能，以进行空气和水分敏感的转化。 支持的设备提案将最终导致发现全新的化学反应性，并提高我们制造许多研究领域感兴趣的分子的能力。