A glovebox for discovery of new metal-catalyzed methods

用于发现新金属催化方法的手套箱

• 批准号: 344923-2007
• 负责人: Dong, Vy
• 金额: $ 4.38万
• 依托单位: University of Toronto
• 依托单位国家: 加拿大
• 项目类别: Research Tools and Instruments - Category 1 (<$150,000)
• 财政年份: 2006
• 资助国家: 加拿大
• 起止时间: 2006-01-01 至 2007-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=325885
• 关键词: glovebox; discovery; new; metal; catalyzed

Our research program is motivated by the need for synthetic methods that are more efficient, selective, and environmentally sustainable.  Towards this challenge, we plan to develop innovative ways to functionalize carbon-hydrogen bonds, use carbon dioxide as a raw material, and build nitrogen-containing heterocycles. While these important goals are diverse, our research strategy maintains an essential theme: the discovery of new transition metal-catalysts to rapidly transform readily available reagents into valuable organic products. Transition metal complexes have an amazing ability to make, break, and rearrange bonds within an organic molecule via mechanisms which cannot be accessed using more traditional catalysts (e.g. protic or Lewis acids).  However, many reactive metal-complexes (and their corresponding ligands) are also highly sensitive to oxygen and moisture.  Because manipulation of these air and moisture sensitive species is critical to our proposed research, we are requesting an inert atmosphere dry box or 'glovebox'.  The requested equipment will enable the synthesis, characterization, and application of various ligands and metal-complexes under an inert atmosphere. This technology will enable the discovery of transformations, catalysts, and reagents which would be impossible to discover under normal atmospheric conditions.  In addition, the researchers involved in this program will be trained in the most advanced techniques of modern organic chemistry and develop the necessary skills to perform air and moisture sensitive transformations.     The equipment proposal to be supported will ultimately lead to the discovery of fundamentally new chemical reactivity and enhance our ability to make molecules of interest to many fields of research.

我们的研究计划是出于需要更有效，选择性和环境可持续性的合成方法的激励。面对这一挑战，我们计划开发创新的方法，以使碳氢键功能功能化，使用二氧化碳作为原料，并建立含氮的异细生。尽管这些重要目标是多种多样的，但我们的研究策略仍然具有重要主题：发现新的过渡金属催化剂，以快速将易于使用的试剂转化为有机产品。过渡金属配合物具有通过机制在有机分子中建立，破坏和重新排列键的惊人能力，这些机制无法使用更多传统的催化剂（例如protic或刘易斯酸）访问。但是，许多反应性金属复合物（及其相应的配体）也对氧气和水分高度敏感。由于对这些空气和水分敏感物种的操纵对于我们提出的研究至关重要，因此我们要求惰性大气干盒或“杂物箱”。请求的设备将使各种配体和金属复合物在惰性气氛下的综合，表征和应用。这项技术将使转化，催化剂和试剂的发现能够在正常的大气条件下发现。此外，参与该计划的研究人员将接受现代有机化学最先进的技术的培训，并发展出进行空气和水分敏感转换的必要技能。要支持的设备提案最终将导致从根本上发现新的化学反应性，并增强我们使许多研究领域感兴趣的分子的能力。