Tumour-associated macrophages (TAMs) and their role in breast cancer metastasis

肿瘤相关巨噬细胞（TAM）及其在乳腺癌转移中的作用

• 批准号: nhmrc : 567019
• 负责人: Dr Agnieszka Swierczak
• 金额: $ 4.84万
• 依托单位: The University of Melbourne
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Postgraduate Scholarships
• 财政年份: 2009
• 资助国家: 澳大利亚
• 起止时间: 2009-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/tumour-associated-macrophages-cancer-metastasis/116025
• 关键词: Tumour; associated; macrophages; TAMs; their

Tumour-associated macrophages (TAMs) have been implicated in breast cancer spread. Tumour cell behaviour is influenced by the surrounding environment. This study will determine the relationship of TAMs to other cell populations, if the expression of the enzyme, u-PA, in non-tumour cells within the tumour environment is important for breast cancer spread, and whether TAM precursor white blood cells home to the primary tumour and-or to the site of tumour spread before the arrival of tumour cells.

肿瘤相关巨噬细胞（TAM）与乳腺癌扩散有关。肿瘤细胞的行为受到周围环境的影响。这项研究将确定TAM与其他细胞群的关系，如果在肿瘤环境中的非肿瘤细胞中的酶u-PA的表达对于乳腺癌扩散是重要的，以及TAM前体白色血细胞是否在肿瘤细胞到达之前回到原发肿瘤和/或肿瘤扩散部位。