Uncovering novel roles of Escherichia coli flagella and LPS in uropathogenesis

揭示大肠杆菌鞭毛和 LPS 在尿路病理发生中的新作用

• 批准号: nhmrc : GNT1084889
• 负责人: Prof Glen Ulett
• 金额: $ 39.21万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/uncovering-novel-roles-lps-uropathogenesis/1345586
• 关键词: Uncovering; novel; roles; Escherichia; coli

Urinary tract infections (UTI) are common infectious diseases in humans. Uropathogenic Escherichia coli (UPEC) cause most UTI. UPEC produce factors that promote their survival and influence disease such as flagella. We have identified anti-inflammatory responses as a key element of UTI and have shown that these responses contribute to control of UTI. In this project, we will investigate how the UPEC flagella component, FliC, contributes to anti-inflammatory responses and what this means for UTI.

尿路感染（UTI）是人类常见的传染病。尿路致病性大肠杆菌（UPEC）引起大多数UTI。UPEC产生促进其存活和影响疾病的因子，如鞭毛。我们已经确定抗炎反应是UTI的关键因素，并表明这些反应有助于控制UTI。在这个项目中，我们将研究UPEC鞭毛成分FliC如何有助于抗炎反应以及这对UTI意味着什么。