A matter of life and death: defining novel interactions between uropathogenic E. coli and macrophages that influence UTI pathology

生死攸关：定义影响泌尿道感染病理学的尿路致病性大肠杆菌和巨噬细胞之间的新相互作用

• 批准号: nhmrc : 1068593
• 负责人: Prof Glen Ulett
• 金额: $ 42.88万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2014
• 资助国家: 澳大利亚
• 起止时间: 2014-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/matter-life-death-uti-pathology/455350
• 关键词: matter; life; death; defining; novel

Urinary tract infections (UTI) are one of the most common types of infections in humans. Uropathogenic Escherichia coli (UPEC) are the major microbes causing UTI in humans. This project will define novel interactions between UPEC and macrophages, an important immune cell involved in the control of UTI. The outcomes of this project will be a better understanding of how UPEC causes disease, and potentially new treatment regimes for UTI.

尿路感染（UTI）是人类最常见的感染类型之一。尿路致病性大肠杆菌（UPEC）是引起人类尿路感染的主要微生物。该项目将定义UPEC和巨噬细胞之间的新型相互作用，巨噬细胞是参与控制UTI的重要免疫细胞。该项目的成果将是更好地了解UPEC如何导致疾病，以及UTI的潜在新治疗方案。