Role of Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in infection and potential as a target to control colonization in the female genital tract

无乳链球菌甘油醛 3-磷酸脱氢酶 (GAPDH) 在感染中的作用及其作为控制女性生殖道定植目标的潜力

• 批准号: nhmrc : 1146569
• 负责人: Prof Glen Ulett
• 金额: $ 45.15万
• 依托单位: Griffith University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/role-streptococcus-agalactiae-genital-tract/1320682
• 关键词: Role; Streptococcus; agalactiae; glyceraldehyde; phosphate

Extracellular proteins produced by pathogenic bacteria can facilitate microbial colonization of the host by mediating binding to host cells and by modulating the immune system. These proteins exert their effects by subverting specific elements of the immune system and this can allow infection to worsen. This project will increase our understanding of how this bacterium chronically colonizes humans and will identify the potential of a bacterial protein, termed GAPDH, as a target for control.

由病原菌产生的细胞外蛋白可以通过介导与宿主细胞的结合和通过调节免疫系统来促进宿主的微生物定殖。这些蛋白质通过破坏免疫系统的特定元素来发挥作用，这可能会使感染恶化。该项目将增加我们对这种细菌如何长期定植于人类的理解，并将确定一种称为GAPDH的细菌蛋白质作为控制目标的潜力。