Role of Streptococcus agalactiae glyceraldehyde 3-phosphate dehydrogenase (GAPDH) in infection and potential as a target to control colonization in the female genital tract

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Extracellular proteins produced by pathogenic bacteria can facilitate microbial colonization of the host by mediating binding to host cells and by modulating the immune system. These proteins exert their effects by subverting specific elements of the immune system and this can allow infection to worsen. This project will increase our understanding of how this bacterium chronically colonizes humans and will identify the potential of a bacterial protein, termed GAPDH, as a target for control.