Understanding the critical mechanisms that govern regulatory T cell life and death decisions

了解控制调节性 T 细胞生命和死亡决策的关键机制

• 批准号: nhmrc : 1089072
• 负责人: Dr Charis Teh
• 金额: $ 22.59万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Early Career Fellowships
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-critical-mechanisms-death-decisions/519244
• 关键词: Understanding; critical; mechanisms; govern; regulatory

Autoimmune diseases impose an increasingly large health burden. Treg cells prevents the immune system from attacking “self” offering the promise of using these cells to restore immune balance in autoimmune diseases. However, there are currently no protocols that reliably modify Treg cell numbers. This study will elucidate the mechanisms that govern Treg cell survival and death, revealing potential molecular targets to manipulate the quality and quantity of Treg cell for therapeutic benefit.

自身免疫性疾病造成越来越大的健康负担。 Treg 细胞可防止免疫系统攻击“自身”，这为利用这些细胞恢复自身免疫性疾病中的免疫平衡提供了希望。然而，目前还没有可靠地修改 Treg 细胞数量的方案。这项研究将阐明控制 Treg 细胞存活和死亡的机制，揭示操纵 Treg 细胞质量和数量以获得治疗益处的潜在分子靶标。