Discrimination and Adolescent Substance Use: Understanding Moderating Mechanisms of Sleep and Neighborhood Environment in the ABCD Study

歧视和青少年药物使用：ABCD 研究中睡眠和邻里环境的调节机制

• 批准号: 10470214
• 负责人: Yijie Wang
• 金额: $ 41.49万
• 依托单位: MICHIGAN STATE UNIVERSITY
• 依托单位国家: 美国
• 财政年份: 2021
• 资助国家: 美国
• 起止时间: 2021-09-01 至 2026-04-30
• 项目状态: 未结题
• 来源: https://reporter.nih.gov/project-details/10470214
• 关键词: 10 year old; Address; Adolescence; Adolescent; Adopted; Adult; Age; Brain; Buffers; Categories; Child; Childhood; Country; Crime; Data; Data Analyses; Data Collection; Development; Disadvantaged minority; Discrimination; Environment; Environmental Risk Factor; Ethnic Origin; Exclusion; Foundations; Goals; Hair; Health; Health behavior; Immigration; Individual; Intervention; Life; Link; Longitudinal Studies; Measures; Mental Health; Methodology; Minority Groups; Modeling; Motion; National Institute on Minority Health and Health Disparities; Neighborhoods; Noise; Outcome; Parents; Patient Self-Report; Persons; Physiological; Prejudice; Public Health; Race; Reduce health disparities; Reporting; Research; Risk; Risk Factors; Role; Sampling; Science; Sex Orientation; Shapes; Sleep; Sleep disturbances; Stress and Coping; Testing; Time; Weight; Work; Youth; actigraphy; adolescent substance use; base; behavioral health; biobehavior; cognitive ability; cognitive development; critical developmental period; deprivation; early adolescence; evidence base; experience; follow-up; health disparity; health equity; health inequalities; indexing; innovation; insight; marginalized population; minority health disparity; novel; perceived discrimination; physical conditioning; programs; prospective; psychosocial; racial and ethnic; sleep health; social; social factors; substance use

PROJECT SUMMARY Discrimination contributes to mental and physical health disparities disproportionately disadvantaging minority populations. Yet, the impact of discrimination on behavioral health outcomes such as substance use (SU) is less clear, particularly in early life (e.g. late childhood and early adolescence). By middle adolescence, SU initiation is set in motion triggering subsequent developmental trajectories. Investigating the onset of SU, starting in late childhood, is critical for mitigating its downstream health consequences. There is even less science focused on multilevel factors that alleviate associations between discrimination and SU. This project addresses these gaps in developmental and health disparities science by investigating adolescents' experiences of multiple forms of discrimination (based on ethnicity/race, country of origin, sexual orientation, weight) and SU (self-report & hair sample metabolites) from late childhood to middle adolescence, and by investigating sleep (parent-report & actigraphy duration & quality) and neighborhood environment (deprivation, crime, noise, structural discrimination from geocodes) as moderators of the health impact of discrimination. Both sleep and neighborhood environment can be targeted by evidence-based programming as levers of change to reduce the impact of discrimination on SU. The project draws from the on-going, national, longitudinal study of Adolescent Brain Cognitive Development (ABCD), the largest national study of its kind that follows 11,875 children (9-10 years old) through adolescence. The project examines three research aims. First, the study investigates concurrent and longitudinal linkages between discrimination and SU, from late childhood to early adolescence, disentangling whether discrimination is a contributing or a resulting factor of SU initiation and continuation. Second, the study investigates the extent to which the linkages between discrimination and SU are conditioned by young people's sleep. Finally, the study investigates the moderating role of neighborhood environment in linking discrimination, sleep, and SU, from late childhood to middle adolescence. For all research aims, the proposed project also explores how the associations of discrimination, SU, sleep, and neighborhood environment change from late childhood to adolescence, by testing multiple development-related differences (i.e., by data collection wave, developmental stage, age, grade level). Findings will elucidate critical developmental periods when interventions are most effective in helping young people from marginalized populations (ethnicity/race, immigration status, sexual orientation, and body shape) navigate the negative health consequences of prejudice and exclusion. Essentially, this project will provide critical insights for youth SU programs including who is most at risk, what to target, and when to intervene.

项目总结