Understanding how the Helicobacter pylori pilin protein CagL promotes gastric cancer

了解幽门螺杆菌菌毛蛋白 CagL 如何促进胃癌

• 批准号: nhmrc : GNT1148142
• 负责人: Dr Terry Kwok
• 金额: $ 66.78万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-helicobacter-pylori-gastric-cancer/1348869
• 关键词: Understanding; how; Helicobacter; pylori; pilin

The bacterium Helicobacter pylori is a major cause of gastric cancer and chronic gastritis. The bacterial protein CagL is a key disease-causing protein of H. pylori and potent stimulant of host immune responses. This study aims to understand how this virulent bacterial protein promotes cancer development, and to identify novel therapeutic targets and diagnostic markers for better management of gastric cancer and other severe chronic gastric diseases.

幽门螺杆菌是导致胃癌和慢性胃炎的主要原因。细菌蛋白CagL是H.幽门螺杆菌和宿主免疫反应的有效刺激物。这项研究旨在了解这种有毒细菌蛋白如何促进癌症发展，并确定新的治疗靶点和诊断标志物，以更好地管理胃癌和其他严重的慢性胃病。