Understanding immune memory diversity

了解免疫记忆多样性

• 批准号: nhmrc : 1108066
• 负责人: Dr Kim Jacobson
• 金额: $ 28.84万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Career Development Fellowships
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-immune-memory-diversity/663020
• 关键词: Understanding; immune; memory; diversity

Chronic infectious diseases have a devastating effect on global health. HIV and Plasmodium falciparum both cause chronic disease and have evaded effective vaccine design. Vaccines rely on immune memory – the ability to clear an infection rapidly to a previously encountered pathogen. This proposal investigates the formation and dysfunction of immune memory in chronic infectious diseases, which will be vital for creating new and effective vaccines.

慢性传染病对全球健康造成破坏性影响。艾滋病毒和恶性疟原虫都会导致慢性疾病，并且无法有效的疫苗设计。疫苗依赖于免疫记忆——快速清除先前遇到的病原体感染的能力。该提案研究了慢性传染病中免疫记忆的形成和功能障碍，这对于创造新的有效疫苗至关重要。