Epigenetic mechanisms that regulate B cell differentiation and memory B cell persistence to provide long-term immune protection

调节 B 细胞分化和记忆 B 细胞持久性以提供长期免疫保护的表观遗传机制

• 批准号: nhmrc : 1022458
• 负责人: Dr Kim Jacobson
• 金额: $ 21.22万
• 依托单位: The Walter and Eliza Hall Institute of Medical Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/epigenetic-mechanisms-regulate-immune-protection/110190
• 关键词: Epigenetic; mechanisms; regulate; cell; differentiation

Memory immune cells remember antigens that have previously induced an immune response, and the ability of these cells to rapidly clear pathogens has led to successful vaccination programs. This project will study epigenetic changes during the formation of immune memory that results in protection against foreign antigens. Understanding these processes will assist in creating more effective vaccines and treatments for patients with immune disorders.

记忆免疫细胞会记住先前诱导免疫反应的抗原，这些细胞快速清除病原体的能力导致了疫苗接种计划的成功。该项目将研究免疫记忆形成过程中的表观遗传变化，从而产生针对外来抗原的保护。了解这些过程将有助于为患有免疫疾病的患者创造更有效的疫苗和治疗方法。