Understanding immunity to influenza B viruses for a rationally designed universal vaccine

B型流感病毒(IBV)每年传播，在儿童中特别流行和严重。然而，IBV在很大程度上仍未得到充分研究。我们的免疫系统通过各种机制提供对IBV的保护。这项研究将表征对IBV的免疫力，并剖析宿主与病毒之间的相互作用，以提供对IBV感染的保护。该项目将为合理设计诱导对IBV的普遍免疫的新型疫苗提供信息，最终目标是控制IBV。

Influenza B viruses (IBV) circulate annually and are particularly prevalent and severe in children. However, IBV remain largely understudied. Our immune system provides protection against IBV via a variety of mechanisms. This study will characterize the immunity to IBV and dissect host-virus interactions which provide protection from IBV infection. This project will inform the rational design of novel vaccines eliciting universal immunity to IBV, with an ultimate goal of controlling IBV.