Understanding the Interplay Between ER Stress and Inflammation

了解内质网应激和炎症之间的相互作用

• 批准号: nhmrc : 1047905
• 负责人: A/Pr David Serisier
• 金额: $ 37.4万
• 依托单位: The University of Queensland
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-interplay-er-stress-inflammation/111980
• 关键词: Understanding; Interplay; Between; ER; Stress

Chronic inflammatory diseases in the gut and lung affect hundreds of thousands of Australians. We have identified how inflammation causes a type of stress resulting in abnormal protein synthesis in the cells which make the barrier to microbes. Following an infection this process might be the trigger for chronic unresolving inflammatory disease. The further understanding of this process we seek in this project is likely to lead new approaches to treat common inflammatory diseases.

成千上万的澳大利亚人患有肠道和肺部的慢性炎症性疾病。我们已经确定了炎症如何引起一种压力，导致细胞中蛋白质合成异常，从而形成微生物屏障。感染后，这一过程可能引发慢性炎症性疾病。我们在这个项目中寻求的对这一过程的进一步理解可能会导致治疗常见炎症性疾病的新方法。