Long-term macrolide therapy; oropharyngeal dysbiosis and the spread of resistant pathogens

长期大环内酯类药物治疗；

• 批准号: nhmrc : GNT1104000
• 负责人: A/Pr David Serisier
• 金额: $ 38.42万
• 依托单位: Flinders University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/long-term-macrolide-resistant-pathogens/1346323
• 关键词: Long; term; macrolide; therapy; oropharyngeal

Use of macrolide therapy for chronic lung diseases is increasing rapidly. We will determine the impact of long-term macrolide antibiotic use on upper airway bacteria in patients with lung disease, and assess its contribution to antibiotic resistance in the wider community. We will investigate the mechanism by which this therapy achieves benefit and assess interference with bacterial signalling as a means to improve treatment efficacy and reduce induction of antibiotic resistance.

大环内酯治疗慢性肺部疾病的使用正在迅速增加。我们将确定长期使用大环内酯类抗生素对肺部疾病患者上呼吸道细菌的影响，并评估其对更广泛社区抗生素耐药性的贡献。我们将研究这种治疗获得益处的机制，并评估干扰细菌信号作为提高治疗效果和减少抗生素耐药性诱导的一种手段。