UNDERSTANDING THE MOLECULAR MECHANISMS CONTROLLING NUCLEOLAR SURVEILLANCE IN DISEASE

了解疾病中控制核仁监视的分子机制

• 批准号: nhmrc : GNT1102609
• 负责人: Dr George Thomas
• 金额: $ 85.6万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-molecular-mechanisms-surveillance-disease/1346229
• 关键词: UNDERSTANDING; MOLECULAR; MECHANISMS; CONTROLLING; NUCLEOLAR

Alterations in the ability of cells to make ribosomes, the cellular factories that make protein, contribute to a range of diseases including cancer and a class of inherited disorders called ribosomopathies that are rare but largely untreatable. These changes cause disease by controlling the “nucleolar surveillance pathway” that causes cells to either stop dividing or die. Here we propose to identify new genes that regulate this pathway to identify new targets for treating these diseases.

细胞制造核糖体（制造蛋白质的细胞工厂）的能力的改变会导致一系列疾病，包括癌症和一类称为核糖体病的遗传性疾病，这些疾病很罕见，但基本上无法治愈。这些变化通过控制导致细胞停止分裂或死亡的“核仁监视途径”而引起疾病。在这里，我们建议确定调节这一途径的新基因，以确定治疗这些疾病的新靶点。