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Understanding the multistep pathogenesis of T-cell leukaemia

Understanding the multistep pathogenesis of T-cell leukaemia
了解 T 细胞白血病的多步发病机制
批准号:
nhmrc : 1104145
负责人:
A/Pr Matthew Mccormack
金额:
$48.1万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31

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中文摘要
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英文摘要
Lmo2 is a transcription factor whose overexpression is a common cause of T-cell leukaemia. This project seeks to identify downstream targets of Lmo2 that cause T-cell leukemia. In addition, the origins and effects of secondary mutations that collaborate with Lmo2 in causing T-cell leukaemia will be determined. This will improve our understanding of how T-cell leukaemia develops and provide new molecular targets for therapy.
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会议论文
Targeting homeobox genes in Acute Myeloid Leukaemia
  • 批准号:
    nhmrc : 1126772
  • 项目类别:
    Project Grants
  • 资助金额:
    $44.95万
  • 财政年份:
    2017
  • 负责人:
    A/Pr Matthew Mccormack
  • 依托单位:
The role of the homeobox transcription factor Hhex in haematopoiesis and leukaemia
  • 批准号:
    nhmrc : 1085765
  • 项目类别:
    Project Grants
  • 资助金额:
    $41.55万
  • 财政年份:
    2015
  • 负责人:
    A/Pr Matthew Mccormack
  • 依托单位:
Gene therapy, stress haematopoiesis and the risk of malignancy
  • 批准号:
    nhmrc : 632657
  • 项目类别:
    NHMRC Project Grants
  • 资助金额:
    $41.17万
  • 财政年份:
    2010
  • 负责人:
    A/Pr Matthew Mccormack
  • 依托单位:
海外基金