Understanding the multistep pathogenesis of T-cell leukaemia

了解 T 细胞白血病的多步发病机制

• 批准号: nhmrc : 1104145
• 负责人: A/Pr Matthew Mccormack
• 金额: $ 48.1万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 2018-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-multistep-pathogenesis-cell-leukaemia/662724
• 关键词: Understanding; multistep; pathogenesis; cell; leukaemia

Lmo2 is a transcription factor whose overexpression is a common cause of T-cell leukaemia. This project seeks to identify downstream targets of Lmo2 that cause T-cell leukemia. In addition, the origins and effects of secondary mutations that collaborate with Lmo2 in causing T-cell leukaemia will be determined. This will improve our understanding of how T-cell leukaemia develops and provide new molecular targets for therapy.

LMO2是一种转录因子，其过度表达是T细胞白血病的常见原因。该项目旨在确定导致T细胞白血病的Lmo2下游靶点。此外，将确定与Lmo2合作导致T细胞白血病的次级突变的来源和影响。这将提高我们对T细胞白血病如何发展的理解，并为治疗提供新的分子靶点。