Understanding the multistep pathogenesis of T-cell leukaemia
Understanding the multistep pathogenesis of T-cell leukaemia
批准号:
nhmrc : 1104145
负责人:
A/Pr Matthew Mccormack
金额:
$48.1万
依托单位:
依托单位国家:
澳大利亚
项目类别:
Project Grants
财政年份:
2016
资助国家:
澳大利亚
项目状态:
已结题
起止时间:
2016-01-01 至 2018-12-31
中文摘要
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英文摘要
Lmo2 is a transcription factor whose overexpression is a common cause of T-cell leukaemia. This project seeks to identify downstream targets of Lmo2 that cause T-cell leukemia. In addition, the origins and effects of secondary mutations that collaborate with Lmo2 in causing T-cell leukaemia will be determined. This will improve our understanding of how T-cell leukaemia develops and provide new molecular targets for therapy.
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会议论文
Targeting homeobox genes in Acute Myeloid Leukaemia
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批准号:nhmrc : 1126772
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项目类别:Project Grants
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资助金额:$44.95万
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财政年份:2017
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负责人:A/Pr Matthew Mccormack
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依托单位:
The role of the homeobox transcription factor Hhex in haematopoiesis and leukaemia
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批准号:nhmrc : 1085765
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项目类别:Project Grants
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资助金额:$41.55万
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财政年份:2015
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负责人:A/Pr Matthew Mccormack
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依托单位:
Gene therapy, stress haematopoiesis and the risk of malignancy
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批准号:nhmrc : 632657
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项目类别:NHMRC Project Grants
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资助金额:$41.17万
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财政年份:2010
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负责人:A/Pr Matthew Mccormack
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依托单位:
海外基金