Targeting homeobox genes in Acute Myeloid Leukaemia

靶向急性髓系白血病的同源框基因

• 批准号: nhmrc : 1126772
• 负责人: A/Pr Matthew Mccormack
• 金额: $ 44.95万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2017
• 资助国家: 澳大利亚
• 起止时间: 2017-01-01 至 2019-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/targeting-homeobox-genes-myeloid-leukaemia/947857
• 关键词: Targeting; homeobox; genes; Acute; Myeloid

Acute myeloid leukaemia (AML) is a common blood cancer with dire clinical prognosis due to a lack of targeted molecular therapies. In this proposal we will identify new ways of targeting transcription factor proteins that are overexpressed in AML and promote leukaemia by repressing normal cellular growth controls. This may lead to novel methods to target leukaemic stem cells to specifically eliminate myeloid leukemia

急性髓性白血病（AML）是一种常见的血液肿瘤，由于缺乏靶向分子治疗，临床预后不良。在这项提案中，我们将确定靶向转录因子蛋白的新方法，这些转录因子蛋白在AML中过表达，并通过抑制正常的细胞生长控制来促进白血病。这可能导致新的方法靶向白血病干细胞，以特异性消除髓系白血病