Understanding pathogenicity and immunity in an encephalitic mouse model of Hendra virus infection

了解亨德拉病毒感染脑炎小鼠模型的致病性和免疫性

• 批准号: nhmrc : 1042546
• 负责人: A/Pr John Stambas
• 金额: $ 38.16万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: Targeted Calls
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-pathogenicity-immunity-virus-infection/111484
• 关键词: Understanding; pathogenicity; immunity; encephalitic; mouse

Our understanding of Hendra virus infection and immunity is extremely limited and has been hampered by a lack of appropriate animal models of disease and reagents. This Project will employ a newly-established mouse model to study encephalitis, the most life-threatening manifestation of this infection. We will use unique, state-of-the-art infrastructure and a plethora of mouse-specific reagents to investigate the mechanisms involved in regulating the host response to infection.

我们对亨德拉病毒感染和免疫的了解非常有限，并且由于缺乏适当的疾病动物模型和试剂而受到阻碍。本项目将采用一种新建立的小鼠模型来研究脑炎，这是这种感染最危及生命的表现。我们将使用独特的，最先进的基础设施和大量的小鼠特异性试剂来研究调节宿主对感染反应的机制。