Evaluation of immune correlates for virus-specific CD8+ T cells following prime-boost vaccination

初次加强疫苗接种后病毒特异性 CD8 T 细胞免疫相关性的评估

• 批准号: nhmrc : 508902
• 负责人: A/Pr John Stambas
• 金额: $ 26.53万
• 依托单位: Deakin University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/evaluation-immune-correlates-boost-vaccination/76192
• 关键词: Evaluation; immune; correlates; virus; specific

This project will use cutting-edge technology to evaluate the quality of virus-specific white blood cells generated following vaccination. Clinically relevant vaccination strategies will be analysed in a well characterised mouse model of infection to produce correlates associated with protective vaccine efficacy, particularly in an immunosupressed setting. This will lead to more focused research and ultimately the development of prophylactic and therapeutic HIV vaccines.

该项目将利用尖端技术来评估疫苗接种后产生的病毒特异性白细胞的质量。将在特征明确的小鼠感染模型中分析临床相关的疫苗接种策略，以产生与保护性疫苗功效相关的相关性，特别是在免疫抑制的环境中。这将导致更有针对性的研究，并最终开发出预防性和治疗性艾滋病毒疫苗。