Improving the management of an emerging viral disease in Australia: determination of the mechanisms of neuroinvasion by Hendra virus and their control, leading to optimisation of post-exposure therapy following contact with Hendra virus

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Hendra virus causes severe disease in people with >50% mortality; human infection is acquired following contact with affected horses. In nature, Hendra virus is carried by flying foxes and the cause of spill-over events to horses is unknown. The impact of Hendra virus on human health may rapidly increase in response to continued urban expansion; the outcome of this project will be improved decision support for those charged with the medical management of people exposed to this deadly virus.