Understanding the pharmacoregulation of the extracellular calcium sensing receptor.

钙敏感受体（CaSR）是激素释放和肾脏运输、消化-吸收-饱腹感和骨量的重要调节因子。在每种情况下，casr都采用一种独特的激活机制，我们将详细阐明这种机制，以开发新的化疗方法，例如骨质疏松症和肥胖症。我们也期望早期应用基于casr的治疗方法来治疗临床上重要的遗传性疾病，如新生儿甲状旁腺功能亢进。

Calcium sensing receptors (CaSR) are important regulators of hormone release and modulators of kidney transport, digestion-absorption-satiety and bone mass. In each case, CaSRs adopt a characteristically distinct activating mechanism that we will unravel in detail sufficient for the development of novel chemotherapies e.g., for osteoporosis and obesity. We also anticipate early application of CaSR-based therapies to clinically significant genetic disorders e.g., neonatal hyperparathyroidism.