Nutrient dependent signalling in bone via calcium sensing receptors

骨质疏松症是一个主要的健康问题，影响了多达10%的澳大利亚社区，每年花费数百万美元的卫生预算。一些关键的营养因素，包括钙和膳食蛋白质的摄入，在骨质疏松症的发展中是重要的。这一提议将验证一个假设，即人类骨细胞表达一种能感知钙和氨基酸的蛋白质，即钙感知受体，从而对血浆中钙离子和氨基酸的存在产生的营养信号做出反应。此外，我们提出钙敏感受体通过促进成骨细胞的增殖、成熟和存活，是膳食钙和蛋白质促进骨形成的关键分子机制。这些研究有可能解释bpne吸收活性（提高局部钙浓度）与骨形成活性以及骨形成和吸收活性耦合之间的关系。这些研究有可能解释钙和蛋白质摄入对骨量的积极影响，也可能阐明成骨细胞和破骨细胞活动之间耦合的调节

Osteoporosis is a major health problem that affects as many as 10% of the Australian Community and costs the health budget millions of dollars each year. A number of key nutritional factors including calcium and dietary protein intake are known to be important in the development of osteoporosis. This proposal will test the hypothesis that human bone cells express a protein which senses calcium and amino acids, the calcium-sensing receptor, and thereby respond to nuritional signals arising from the presence of calcium ions and amino acids in plasma. Furthermore, we propose that by promoting osteoblast proliferation, maturation and survival, the calcium sensing receptor acts as the key molecular mechanism by which dietary calcium and protein promotes bone formation.These studies have potential to explain relationships between bpne resorptive activity, which raises local calcium concentrations, and bone formation activity and the coupling of bone forming and resorbing activity. These studies have the potential to explain the positive effects of calcium and protein intake on bone mass and may also shed light on the regulation of the coupling between osteoblastic and osteoclastic activity