Understanding respiratory infections to improve vaccines

在世界上，土著儿童患耳部疾病和相关听力损失的比率最高。巴布亚新几内亚是西太平洋区域儿童死亡率最高的国家，23%的儿童死于肺炎。可以通过扩大对致病病原体的覆盖范围来改进OM和肺炎疫苗。这项研究将确定目前在巴布亚新几内亚土著儿童中引起OM和肺炎的病原体，并将测量对这些病原体的免疫反应，以便开发改进的疫苗。

Indigenous children have the highest rates of ear disease (OM) and associated hearing loss in the world. Papua New Guinea has the highest child mortality rates in the Western Pacific Region with 23% of deaths from pneumonia. OM and pneumonia vaccines can be improved through broadening their coverage of disease-causing pathogens. This study will identify the pathogens that currently cause OM in Indigenous children and pneumonia in PNG, and will measure the immune responses to these pathogens, in order to develop improved vaccines.