Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施
基本信息
- 批准号:10772418
- 负责人:
- 金额:$ 7.8万
- 依托单位:
- 依托单位国家:美国
- 项目类别:
- 财政年份:2021
- 资助国家:美国
- 起止时间:2021-04-13 至 2024-08-31
- 项目状态:已结题
- 来源:
- 关键词:AddressAdolescenceAdolescent and Young AdultAgeAlabamaBacteriaBehaviorBehavioralBiologicalBiological FactorsCarbohydratesCaringCariogenic DietCaucasiansCessation of lifeChronicClinicalCystic FibrosisDataDentalDental HygieneDental PlaqueDental cariesDentistryDentistsDiagnosticDiseaseEnrollmentEnvironmentEpidemiologyEvidence based interventionGeneral PopulationGingivitisHealthHealth behaviorImpairmentIncidenceInflammatoryIntakeInterventionLifeLife ExpectancyLinkLungLung diseasesMeasuresMechanical ventilationMedicalMethodsModelingModernizationMouth DiseasesMucociliary ClearanceNorth CarolinaObstructive Lung DiseasesOralOral cavityOral healthOutcomePathogenicityPathway interactionsPatientsPediatric HospitalsPneumoniaPopulationPrevalencePreventionPreventivePreventive dental carePulmonary Cystic FibrosisPulmonary Function Test/Forced Expiratory Volume 1Quality of lifeRefluxRespiratory Tract InfectionsRiskRisk FactorsSalivaSiteSourceSputumStandardizationStomachStreptococcus mutansTimeUniversitiesVisitWeightage groupaspirateautosomechildren with cystic fibrosiscohortcystic fibrosis patientsdisorder preventiondysbiosisearly adolescencefunctional declinehigh riskimprovedloss of functionlung injurylung microbiomemicrobiomemicrobiome analysisoral bacteriaoral microbiomepathogenic bacteriapeerprematurepreventpreventive interventionprospectivepulmonary functionpulmonary function declinerandomized, clinical trialsrespiratoryrespiratory health
项目摘要
Abstract
Cystic fibrosis (CF) is the most common life-limiting autosomal recessive disease in Caucasians. Impaired
mucociliary clearance predisposes individuals with CF to chronic respiratory infections, resulting in progressive
lung damage and premature death. We and others have shown that oral bacteria infect the lungs in individuals
with CF at high concentrations. Caries and gingivitis are associated with an increased abundance of
pathogenic and often proinflammatory intraoral bacteria that can be aspirated. Dental plaque flora can cause
pneumonia, for example in mechanically-ventilated patients. Given the broader evidence of oral-respiratory
links, it is surprising that the association between oral diseases and respiratory health in CF has never been
evaluated, even though there is a plausible microbiological mechanism. The overall hypothesis of this proposal
is that oral diseases, defined as caries and gingivitis, are potentially modifiable contributors to lung disease in
CF. In this 5-year observational U01, we will enroll 210 adolescents and young adults with CF ages 12 to 30
years at 3 sites: Seattle Children’s Hospital, the University of North Carolina Chapel Hill, and the University of
Alabama at Birmingham. The study will involve 3 study visits over 24 months. We will obtain quantitative and
qualitative data on risk factors for oral diseases; perform a standardized assessment of caries and gingivitis;
evaluate respiratory health outcomes; and collect sputum, saliva, and plaque for microbiome analyses. The
Aims are to: (1) Describe the prevalence and incidence of oral diseases in adolescents and young
adults with CF and identify corresponding risk factors with an emphasis on how to improve key oral
health behaviors; (2) Evaluate cross-sectional and longitudinal associations between oral diseases and
respiratory outcomes; and (3) Explore microbiome pathways that link oral and respiratory health. The
proposed study will be the largest and first longitudinal CF oral health study to date, and the first to evaluate
respiratory outcomes associated with oral diseases in CF. Our long-term objective is to develop behavioral
randomized clinical trials for adolescents and young adults with CF to prevent oral diseases and protect
respiratory health. We also seek to elucidate mechanisms that explain the systemic health consequences of
oral diseases. More broadly, our approach provides a framework for improving the oral health of medically
compromised populations through critical epidemiologic inquiry and evidence-based interventions.
抽象的
囊性纤维化(CF)是白种人中最常见的限制生命的常染色体隐性遗传疾病。受损
粘液纤毛清除功能使 CF 患者易患慢性呼吸道感染,从而导致进行性进展
肺部损伤和过早死亡。我们和其他人已经证明口腔细菌会感染个体的肺部
与高浓度的CF。龋齿和牙龈炎与牙周组织丰富度的增加有关。
可以吸出的致病性且通常促炎的口腔内细菌。牙菌斑菌群可引起
肺炎,例如机械通气患者的肺炎。鉴于口腔呼吸系统的更广泛证据
联系,令人惊讶的是,CF 中口腔疾病与呼吸系统健康之间的关联从未被研究过。
尽管存在合理的微生物机制,但仍进行了评估。本提案的总体假设
被定义为龋齿和牙龈炎的口腔疾病是肺部疾病的潜在可改变因素
CF。在这项为期 5 年的 U01 观察中,我们将招募 210 名年龄在 12 至 30 岁之间患有 CF 的青少年和年轻人
在 3 个地点工作多年:西雅图儿童医院、北卡罗来纳大学教堂山分校和北卡罗来纳大学
阿拉巴马州在伯明翰。该研究将涉及 24 个月内的 3 次研究访问。我们将获得定量和
关于口腔疾病危险因素的定性数据;对龋齿和牙龈炎进行标准化评估;
评估呼吸系统健康结果;并收集痰液、唾液和菌斑进行微生物组分析。这
目的是: (1) 描述青少年口腔疾病的患病率和发病率
患有 CF 的成人并确定相应的危险因素,重点是如何改善关键的口腔
健康行为; (2) 评估口腔疾病与口腔疾病之间的横断面和纵向关联
呼吸系统结果; (3) 探索连接口腔和呼吸系统健康的微生物组途径。这
拟议的研究将是迄今为止最大的、第一个纵向 CF 口腔健康研究,也是第一个评估
与 CF 口腔疾病相关的呼吸结果。我们的长期目标是培养行为
针对患有 CF 的青少年和年轻人预防口腔疾病和保护的随机临床试验
呼吸系统健康。我们还试图阐明解释系统健康后果的机制
口腔疾病。更广泛地说,我们的方法为改善医学上的口腔健康提供了一个框架
通过严格的流行病学调查和循证干预措施来帮助受影响的人群。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Donald Leslie Chi其他文献
Donald Leslie Chi的其他文献
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{{ truncateString('Donald Leslie Chi', 18)}}的其他基金
Testing a Mobile App to Improve Toothbrushing Skills and Habits in Teens with Autism.
测试移动应用程序以提高自闭症青少年的刷牙技能和习惯。
- 批准号:
10738080 - 财政年份:2023
- 资助金额:
$ 7.8万 - 项目类别:
Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施
- 批准号:
10181640 - 财政年份:2021
- 资助金额:
$ 7.8万 - 项目类别:
Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施
- 批准号:
10392478 - 财政年份:2021
- 资助金额:
$ 7.8万 - 项目类别:
Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions.
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施。
- 批准号:
10664785 - 财政年份:2021
- 资助金额:
$ 7.8万 - 项目类别:
Understanding Oral Diseases in Cystic Fibrosis to Develop Tailored Preventive Dental Interventions
了解囊性纤维化中的口腔疾病以制定量身定制的预防性牙科干预措施
- 批准号:
10571699 - 财政年份:2021
- 资助金额:
$ 7.8万 - 项目类别:
Reducing Sugared Fruit Drinks in Alaska Native Children
减少阿拉斯加原住民儿童的含糖水果饮料
- 批准号:
10115247 - 财政年份:2020
- 资助金额:
$ 7.8万 - 项目类别:
Reducing Sugared Fruit Drinks in Alaska Native Children
减少阿拉斯加原住民儿童的含糖水果饮料
- 批准号:
9924503 - 财政年份:2019
- 资助金额:
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Reducing Sugared Fruit Drinks in Alaska Native Children
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10192501 - 财政年份:2019
- 资助金额:
$ 7.8万 - 项目类别:
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10237416 - 财政年份:2018
- 资助金额:
$ 7.8万 - 项目类别:
Developing Topical Fluoride Hesitancy Measures for Causal Modeling and Intervention Research
为因果建模和干预研究制定局部氟化物犹豫措施
- 批准号:
9982681 - 财政年份:2018
- 资助金额:
$ 7.8万 - 项目类别:
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