Understanding The Role of Human Lens UV Filters in Age-Related Cataract

了解人体晶状体紫外线过滤器在年龄相关性白内障中的作用

• 批准号: nhmrc : 162707
• 负责人: A/Pr Joanne Jamie
• 金额: $ 15.14万
• 依托单位: University of Wollongong
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-human-related-cataract/96368
• 关键词: Understanding; Role; Human; Lens; UV

Cataract is the most common cause of blindness worldwide, The cause of cataract is currently unknown and the only treatment available at present is surgery. This represents a huge burden on the Health budgets of all developed nations, including Australia. It has been estimated that if a treatment could be developed that simply delayed the onset of cataract by 10 years, the need for surgery would be halved. The savings to the Health budget in the USA alone would be approximately $2 billion (US). We believe, on the basis of our previous research, that human lens UV filter compounds play a major role in the protein modification that is the hallmark of age-related cataract and indeed may be the key factor in precipitating cataract. This proposal seeks to confirm this hypothesis. If this theory is confirmed, it opens the door to pharmacological intervention for cataract by, for example, treating patients (or possibly all people in middle age) with drugs that inhibit the synthesis of the UV filter compounds.

白内障是世界范围内最常见的致盲原因，目前白内障的病因尚不清楚，目前唯一可用的治疗方法是手术。这对包括澳大利亚在内的所有发达国家的卫生预算构成了巨大负担。据估计，如果能够开发出一种治疗方法，将白内障的发病时间推迟10年，手术的需要将减少一半。仅在美国，卫生预算就可节省约20亿美元。我们相信，在我们以前的研究的基础上，人类透镜紫外线过滤化合物在蛋白质修饰中起主要作用，蛋白质修饰是年龄相关性白内障的标志，并且确实可能是诱发白内障的关键因素。本提案试图证实这一假设。如果这一理论得到证实，它将为白内障的药物干预打开大门，例如，用抑制紫外线过滤化合物合成的药物治疗患者（或可能是所有中年人）。