Alternative Medicines from Medicinal Plants of Aboriginal People of Northern New South Wales

新南威尔士州北部原住民药用植物的替代药物

• 批准号: nhmrc : 488504
• 负责人: A/Pr Joanne Jamie
• 金额: $ 10.03万
• 依托单位: Macquarie University
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2008
• 资助国家: 澳大利亚
• 起止时间: 2008-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/alternative-medicines-medicinal-south-wales/98957
• 关键词: Alternative; Medicines; Medicinal; Plants; Aboriginal

This research will conserve customary Australian Aboriginal knowledge of historical and cultural significance and apply this knowledge to the discovery of new evidence-based alternative medicines that may help address the growing need for new antimicrobial treatments. It will also be a model for collaboration between Australian Aboriginal communities and research scientists. The customary (traditional and contemporary) knowledge of medicinal plants possessed by Indigenous peoples is a significant medicinal resource, as seen by the reliance on customary medicines by ~80% of the population in developing countries as their primary healthcare. There has been a renewed interest in customary medicines, especially with the increase in microbial resistance and emergence of new diseases, side effects of single compound medications and high cost of drug development. Australian Aboriginal people have a vast medicinal plant knowledge based on thousands of years of using plants as medicines. This especially includes topical use for conditions indicative of microbial infections. Despite their potential, relatively few studies have been conducted on Australian Aboriginal medicines to provide evidence for their use. For Northern New South Wales (NNSW) Aboriginal communities, as is the case for many other Australian Aboriginal communities, this customary knowledge is rapidly disappearing, especially due to premature deaths of the elder custodians of this knowledge. The overall aims of this project are to work in partnership with the NNSW Yaegl Local Aboriginal Land Council and Ulgundahi Elders Aboriginal Corporation to i) document and preserve first hand customary medicinal plant knowledge; ii) identify plants of significant medicinal potential in treating antibacterial and antifungal infections; iii) evaluate their effectiveness using in vitro and in vivo biological assays; and iv) identify the major bioactive components responsible for their medicinal properties.

这项研究将保存澳大利亚土著人具有历史和文化意义的传统知识，并将这些知识应用于发现新的循证替代药物，这可能有助于满足对新的抗菌治疗日益增长的需求。它也将成为澳大利亚土著社区和研究科学家之间合作的典范。土著人民所拥有的关于药用植物的习惯（传统和当代）知识是一种重要的医药资源，发展中国家约80%的人口依赖传统药物作为其初级保健。人们对传统药物重新产生了兴趣，特别是随着微生物抗药性的增加和新疾病的出现，单一化合物药物的副作用和药物开发的高成本。澳大利亚原住民拥有丰富的药用植物知识，这是基于数千年来使用植物作为药物的基础上。这尤其包括用于指示微生物感染的病症的局部使用。尽管澳大利亚土著药物具有潜力，但对它们进行的研究相对较少，无法提供使用这些药物的证据。对于新南威尔士州北方土著社区来说，与澳大利亚许多其他土著社区一样，这种习惯知识正在迅速消失，特别是由于这种知识的年长保管人过早死亡。该项目的总体目标是与北南威尔士州Yaegl地方土著土地理事会和Ulgundahi长老土著公司合作，一）记录和保存第一手的传统药用植物知识;二）确定在治疗抗菌和抗真菌感染方面具有重要药用潜力的植物;三）使用体外和体内生物测定法评估其有效性;和iv）鉴定负责其药用特性的主要生物活性成分。