Understanding the role of the two major bacterial pathogens in the upper and lower airways of Indigenous children with chronic lung disease

了解两种主要细菌病原体在患有慢性肺病的土著儿童上呼吸道和下呼吸道中的作用

• 批准号: nhmrc : GNT1100310
• 负责人: A/Pr Heidi Smith-Vaughan
• 金额: $ 74.33万
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2016
• 资助国家: 澳大利亚
• 起止时间: 2016-01-01 至 无数据
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-major-lung-disease/1346113
• 关键词: Understanding; role; two; major; bacterial

Lung infections are a major disease burden worldwide. Indigenous Australians are affected more; adults with severe lung disease can die in their 30s and 40s. These diseases start early, yet no in-depth studies of bacteria causing lung infections in children have been done. Our expert team proposes to use existing lung fluids from nearly 500 children with chronic lung disease (58% Indigenous), and state-of-the-art laboratory methods, to inform the design of vaccines to prevent lung disease.

肺部感染是世界范围内的一个主要疾病负担。澳大利亚土著居民受到的影响更大；患有严重肺部疾病的成年人可能在三四十岁时死亡。这些疾病发病较早，但尚未对引起儿童肺部感染的细菌进行深入研究。我们的专家组建议利用现有的近500名患有慢性肺病的儿童（58%为土著居民）的肺液和最先进的实验室方法，为设计预防肺病的疫苗提供信息。