Pneumococcal conjugate vaccine (PCV) schedules for the Northern Territory (NT): randomised controlled trial of booster vaccines to broaden and strengthen protection from invasive and mucosal infections.

北领地 (NT) 肺炎球菌结合疫苗 (PCV) 时间表：加强疫苗的随机对照试验，以扩大和加强对侵袭性和粘膜感染的保护。

• 批准号: nhmrc : 1046999
• 负责人: A/Pr Heidi Smith-Vaughan
• 金额: $ 138.62万
• 依托单位: Menzies School of Health Research
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/pneumococcal-conjugate-vaccine-mucosal-infections/111895
• 关键词: Pneumococcal; conjugate; vaccine; PCV; schedules

Very few Indigenous children in remote communities have healthy ears or lungs; almost 20% have eardrum perforations. The associated hearing loss causes educational disadvantage with life long impacts on quality of life. New pneumococcal conjugate vaccines target a broader diversity of pathogens that cause eardrum perforation and lung infections, but the best schedules and combinations have not been tested. This randomised controlled trial will compare immune response, bacterial carriage and clinical outcomes of different vaccine schedules.

偏远社区的土著儿童很少有健康的耳朵或肺；近20%的患者有耳膜穿孔。相关的听力损失导致教育劣势，对生活质量产生终身影响。新的肺炎球菌结合疫苗针对引起耳膜穿孔和肺部感染的更广泛的病原体，但最佳时间表和组合尚未经过测试。这项随机对照试验将比较不同疫苗接种计划的免疫反应、细菌携带和临床结果。