Understanding the role of chromosome condensation proteins and their link to disease

了解染色体缩合蛋白的作用及其与疾病的联系

• 批准号: nhmrc : 1047009
• 负责人: Dr Damien Hudson
• 金额: $ 40.09万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2013
• 资助国家: 澳大利亚
• 起止时间: 2013-01-01 至 2016-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-role-chromosome-link-disease/111897
• 关键词: Understanding; role; chromosome; condensation; proteins

Cells divide through a complex cascade of signals from our genetic material (DNA) which need to be finely tuned for events to occur properly. Errors in control cause faulty cell division and lead to diseases such as cancer. We have identified a master controller of these events termed the condensin complex and aim to understand how it orchestrates these functions by creating a map of its DNA location and understanding which regions in the genetic material it controls and how.

细胞通过来自我们的遗传物质（DNA）的复杂信号级联进行分裂，这些信号需要进行微调以使事件正确发生。控制错误会导致细胞分裂错误，并导致癌症等疾病。我们已经确定了这些事件的主控制器，称为凝聚素复合物，旨在通过创建其DNA位置的地图并了解它控制遗传物质中的哪些区域以及如何控制来了解它如何协调这些功能。