Understanding the structure and function of the chromosome condensin complex

了解染色体凝缩蛋白复合物的结构和功能

• 批准号: nhmrc : 1030358
• 负责人: Dr Damien Hudson
• 金额: $ 41.39万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2012
• 资助国家: 澳大利亚
• 起止时间: 2012-01-01 至 2015-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-structure-function-condensin-complex/110749
• 关键词: Understanding; structure; function; chromosome; condensin

In order to survive cells need to divide their genetic material (DNA) equally between two daughter cells. For correct cell division to occur DNA has to be correctly packaged into condensed and organised chromosomes. Improper packaging of genetic material can result in unregulated cells that may become cancerous or lead to other genetic diseases such as Down's Syndrome. Understanding the key players regulating this process is vital to allowing researchers to further work in these areas.

为了生存，细胞需要在两个子细胞之间平均分配它们的遗传物质(DNA)。为了进行正确的细胞分裂，DNA必须被正确地包装成浓缩和有组织的染色体。对遗传物质的不当包装可能会导致不受调控的细胞，这些细胞可能会变得癌症或导致其他遗传性疾病，如唐氏综合症。了解调控这一过程的关键因素对于使研究人员能够在这些领域进一步开展工作至关重要。