Understanding how RUVBL1 and RUVBL2 organise chromosomes and their links to disease

了解 RUVBL1 和 RUVBL2 如何组织染色体及其与疾病的联系

• 批准号: nhmrc : 1145188
• 负责人: Dr Damien Hudson
• 金额: $ 40.91万
• 依托单位: Murdoch Childrens Research Institute
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2018
• 资助国家: 澳大利亚
• 起止时间: 2018-01-01 至 2021-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-ruvbl1-ruvbl2-links-disease/1320391
• 关键词: Understanding; how; RUVBL1; RUVBL2; organise

Our proposal will provide a deep mechanistic framework to inform both clinicians in diagnosis and management of RUVBL related diseases and also therapeutically, as industry looks to use these proteins as drug targets. The great excitement of RUVBL in translation has outpaced the gathering of vital knowledge underpinning the function; knowledge this proposal will provide for the first time.

我们的提案将提供一个深入的机制框架，为临床医生提供RUVBL相关疾病的诊断和管理以及治疗方面的信息，因为行业希望将这些蛋白质用作药物靶标。RUVBL在翻译方面的巨大兴奋已经超过了对支撑该功能的重要知识的收集;本提案将首次提供知识。