Understanding tumour plasticity and the microenvironment using single-cell technologies to identify novel targets for metastatic castration-resistant prostate cancer

使用单细胞技术了解肿瘤可塑性和微环境，以确定转移性去势抵抗性前列腺癌的新靶点

• 批准号: nhmrc : 2003115
• 金额: $ 65.36万
• 依托单位国家: 澳大利亚
• 项目类别: Ideas Grants
• 财政年份: 2021
• 资助国家: 澳大利亚
• 起止时间: 2021-01-01 至 2023-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/understanding-tumour-plasticity-prostate-cancer/1780065
• 关键词: Understanding; tumour; plasticity; microenvironment; using

Most prostate cancer patients respond well to treatment, but some develop metastatic disease and respond poorly. During metastasis the cancer spreads to multiple organs and new combinations of genes become activated, making it difficult to develop new treatments. We will investigate these patterns of activation of genes in metastatic samples and how the immune system interacts with the cancer. We will use computational models to identify new drug targets and evaluate immunotherapy as an option.

大多数前列腺癌患者对治疗反应良好，但有些患者发展为转移性疾病，反应较差。在转移过程中，癌症扩散到多个器官，新的基因组合被激活，这使得开发新的治疗方法变得困难。我们将研究这些转移性样本中基因激活的模式以及免疫系统如何与癌症相互作用。我们将使用计算模型来确定新的药物靶点，并评估免疫疗法作为一种选择。