Unraveling the link between HLA B27 and autoimmunity

揭开 HLA B27 与自身免疫之间的联系

• 批准号: nhmrc : 1085017
• 负责人: Dr Tony Kenna
• 金额: $ 49.75万
• 依托单位: Monash University
• 依托单位国家: 澳大利亚
• 项目类别: Project Grants
• 财政年份: 2015
• 资助国家: 澳大利亚
• 起止时间: 2015-01-01 至 2017-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/unraveling-link-hla-b27-autoimmunity/519054
• 关键词: Unraveling; link; between; HLA; B27

Ankylosing spondylitis and related diseases cause significant morbidity in up to 0.25% of the population. Current treatments have limited efficacy and often debilitating side effects. More targeted peptide antigen based therapies will have fewer side effects and would be of major clinical importance to this group of diseases. This project seeks to identify peptide antigens that could be used in targeted immunotherapy. We also seek to understand how some of the idiosyncratic properties of HLA B27

强直性脊柱炎及相关疾病导致高达 0.25% 的人口显着发病。目前的治疗方法疗效有限，而且常常产生使人衰弱的副作用。基于更有针对性的肽抗原的疗法将具有更少的副作用，并且对于此类疾病具有重要的临床意义。该项目旨在鉴定可用于靶向免疫治疗的肽抗原。我们还试图了解 HLA B27 的一些特殊特性如何