The Use of a Multidrug Pill in Reducing Cardiovascular Events (UMPIRE) trial

使用多药丸减少心血管事件 (UMPIRE) 试验

• 批准号: nhmrc : 571456
• 负责人: Prof Anthony Rodgers
• 金额: $ 20.97万
• 依托单位: The University of Sydney
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Strategic Awards
• 财政年份: 2010
• 资助国家: 澳大利亚
• 起止时间: 2010-01-01 至 2012-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/use-multidrug-pill-umpire-trial/99987
• 关键词: Use; Multidrug; Pill; Reducing; Cardiovascular

Patients who have cardiovascular disease are at very high risk of experiencing a heart attack or stroke, and current guidelines recommend the long-term use of aspirin, blood pressure lowering drugs and a cholesterol lowering drug in such patients to reduce their risks. The proposed research will investigate whether the availability of a polypill (a single pill containing all these drugs) will help ensure patients are appropriately prescribed these treatments, and keep taking them long-term. Australian researchers will have a pivotal role in collecting and interpreting the data in this trial. In addition, Australian researchers will combine the findings of this study with results from similar trials being conducted in Australia (1600 patients, including 600 Aboriginal participants) and New Zealand (600 patients, including 600 Maori participants). This overview will provide very accurate information about the usefulness of the polypill, and how it should be used worldwide.

患有心血管疾病的患者发生心脏病发作或中风的风险非常高，目前的指南建议长期使用阿司匹林，降血压药物和降胆固醇药物，以降低这些患者的风险。这项拟议中的研究将调查复合药丸（含有所有这些药物的单一药丸）的可用性是否有助于确保患者适当地接受这些治疗，并长期服用。澳大利亚研究人员将在收集和解释这项试验的数据方面发挥关键作用。此外，澳大利亚研究人员将把这项研究的结果与在澳大利亚（1600名患者，包括600名原住民参与者）和新西兰（600名患者，包括600名毛利人参与者）进行的类似试验的结果进行联合收割机。本概述将提供关于复方制剂的有用性以及如何在全球范围内使用的非常准确的信息。