Collaborative overview of cohort studies of cardiovascular diseases in the Asia Pacific region

亚太地区心血管疾病队列研究合作综述

• 批准号: nhmrc : 107408
• 负责人: Prof Anthony Rodgers
• 金额: $ 15.36万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/collaborative-overview-cohort-pacific-region/94706
• 关键词: Collaborative; overview; cohort; studies; cardiovascular

Throughout Asia and the Pacific, cardiovascular diseases are now a leading cause of death and disability. However, most information about the causes of these diseases comes from studies conducted in North America and Europe, and there are few data available from the Asia Pacific region. Because patterns of cardiovascular diseases and levels of risk factors are very different in the West and East, it is possible that important differences exist in the relative contribution of different factors to disease occurrence in different regions. For example, an earlier project, from which the current study evolved, demonstrated that the association of blood pressure with stroke was about two times steeper in China and Japan than in the West. The present project has been initiated to further investigate the causes of common cardiovascular diseases in populations of the Asia Pacific region. It will involve more than 40 studies conducted in at least 9 countries from the region. These studies include more than 500,000 individuals followed for an average of 8-9 years. Data from 30 studies involving 450,000 individuals has already been provided to the applicants. Analyses will be conducted to provide region-, age-and sex-specific estimates of the effects various risk factors on several types of cardiovascular diseases. The risk factors of interest include: blood pressure, total cholesterol and its subfractions, triglycerides, diabetes, obesity, alcohol consumption, occupation and education. In addition to providing more precise estimates of the effects of established risk factors such as blood pressure, this project will, provide new data on several other risk factors not well investigated in this region. The results should be of importance in determining priorities for cardiovascular disease prevention. They should also be of relevance for predicting changes in the extent of the cardiovascular disease epidemics facing countries in the region.

在整个亚洲及太平洋，心血管疾病现在是死亡和残疾的主要原因。然而，关于这些疾病原因的大部分信息来自北美和欧洲进行的研究，亚太地区的数据很少。由于心血管疾病的模式和危险因素的水平在西部和东部有很大的不同，不同地区不同因素对疾病发生的相对影响可能存在重大差异。例如，一个早期的项目，从目前的研究发展而来，表明中国和日本的血压与中风的关联比西方高出两倍。本项目旨在进一步调查亚太地区人群中常见心血管疾病的原因。它将涉及在该区域至少9个国家进行的40多项研究。这些研究包括超过50万人，平均随访8-9年。涉及45万人的30项研究的数据已经提供给申请人。将进行分析，以提供关于各种危险因素对几种心血管疾病的影响的区域、年龄和性别特定估计数。关注的风险因素包括：血压、总胆固醇及其亚组分、甘油三酯、糖尿病、肥胖、饮酒、职业和教育。除了对血压等已确定的风险因素的影响提供更精确的估计外，该项目还将提供该地区尚未充分研究的其他几个风险因素的新数据。研究结果对于确定心血管疾病预防的优先事项具有重要意义。这些指标还应有助于预测本区域各国面临的心血管疾病流行程度的变化。