Spatio-temporal simultaneous measurements of neurophysiological and hemodynamics signals using dual methods of optical imaging

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The equipment requested in this application is a fast camera system optimized for optical imaging of the brain using special solutions. The molecules of the solutions adhere to the cells in the brain, and emanate light that changes with changes in activity of these cells. The requested system will be combined with an already existing camera system that is capable of imaging blood flow in the brain. This combination will create the first imaging system capable of recording blood signals and brain activity simultaneously. This novel system will support several research programs, all of which are in the field of understanding how brain activity and blood flow in the brain interact. One program seeks to understand this relation under resting condition, when no sensory stimuli or tasks are presented to the subject. A second program investigates the role of different cell types in coordinating the interaction between brain activity and blood flow. A third program will use the system in order to investigate how EEG brain waves are related to blood signals. The fourth program will test existing mathematical models of the interaction between brain activity and blood flow using data obtained by the system.