Rapid Free-Breathing Self-Gated Spiral Pulse Sequences for Simultaneous Cine and T1 mapping

7.项目总结 心力衰竭(HF)是一个主要的公共卫生问题，估计有620万美国人患有心力衰竭 每年有100多万新病例。患有心力衰竭的患者显著降低了 这些患者不仅有生命危险，而且住院和心血管不良后果的风险也很高。有一个不断增长的 认识心脏磁共振成像(CMR)在评估心力衰竭患者中的临床应用。 虽然CMR在心力衰竭评估中的应用越来越广泛，但仍存在一些障碍。 接受并使用此应用程序的CMR。目前的临床研究需要40分钟到一小时 要求患者完成大约40次单独的屏气，持续时间为10-15秒。有很强的 通过创建简化和健壮的自由呼吸、非心电图来提高CMR在心力衰竭中的临床应用的潜力 门控技术，执行起来简单明了。这还将通过以下方式改善患者体验 缩短了研究时间，消除了屏气的需要，而屏气对心衰患者来说尤其困难。 为了解决当前临床技术的这些局限性，我们建议开发并验证一种 技术，电影和T1标测呼吸和心脏自门螺旋采集(CAT-SPARCS)， 其将在5分钟FB非心电门控采集中同时执行电影和T1映射。 在造影剂前后应用这项技术将能够全面评估心脏功能， 原生T1、LGE和ECV在15分钟内完成。这项建议的具体目标是：(1)开发2D CAT-- SPARCS技术在自由呼吸心脏期间同时获取电影、T1图和LGE图像 自门控采集，(2)扩展2D CAT-SPARCS以提供全心同步采集 使用同步多切片(SMS)和3D螺旋采集技术的电影、T1映射和LGE图像， (3)对照临床金标准屏气心电门控临床验证CAT-SPARCS技术 正常受试者和正在接受心衰评估的患者的技术。成功完成这笔赠款将导致 在开发和验证同时进行T1标测和电影成像的高效技术中 这将证明高准确度和重复性，显着缩短了CMR检查。

7. Project Summary Heart failure (HF) is a major public health concern with an estimated 6.2 million Americans suffering from HF and greater than 1 million new cases per year. Patients with HF have significantly reduced quality of life and are at high risk for hospitalization and adverse cardiovascular outcomes. There is a growing recognition of the clinical utility of cardiac magnetic resonance imaging (CMR) for assessing patients with HF. While there is growing utilization of CMR for evaluation of HF, there remain a number of barriers to widespread acceptance and utilization of CMR for this application. Current clinical studies take 40 min to an hour and require the patient to complete about 40 separate breath-holds of 10-15 second duration. There is strong potential to improve the clinical utility of CMR in HF by creating simplified and robust free-breathing, non-ECG gated techniques, which are straightforward to perform. This would also improve the patient experience by shortening the study and eliminating the need for breath-holding, which is particularly difficult for HF patients. To address these limitations of current clinical techniques, we propose to develop and validate a technique, Cine And T1 mapping SPiral Acquisition with Respiratory and Cardiac Self-gating (CAT-SPARCS), which will simultaneously perform cine and T1 mapping in a <5 minute FB non-ECG gated acquisition. Application of this technique pre and post contrast will enable a comprehensive assessment of cardiac function, Native T1, LGE and ECV in under 15-minutes. The specific aims of this proposal are (1) to develop a 2D CAT- SPARCS technique to simultaneously acquire cine, T1 maps and LGE images during a free-breathing cardiac self-gated acquisition, (2) to extend the 2D CAT-SPARCS to provide whole heart simultaneous acquisition of cine, T1 mapping and LGE images using simultaneous multi-slice (SMS) and 3D spiral acquisition techniques, and (3) to validate the CAT-SPARCS technique against the clinical gold standard breath-held ECG-gated clinical techniques in normal subjects and patients being evaluated for HF. Successful completion of this grant will result in the development and validation of a highly efficient technique for simultaneous T1 mapping and cine imaging which will demonstrate high accuracy and repeatability significantly shortening the CMR examination.