A cost and environmentally effective rapid evaporator as a key component of a combinatorial synthesis facility for the generation of new types of bioactive small molecules.

化学生物学和药物化学的进展广泛依赖于高纯度新型小分子的可用性和快速获得。 为了响应这些需求，已经开发了诸如组合化学和微波化学的现代技术，以加速和促进新有机化合物的纯化。 在2004年，我们的部门创建了一个专门的实验室组合合成。 这个现代化的实验室为化学生物学和药物化学的研究人员提供支持。 为了生产大量的小分子，这个设施需要一系列的仪器，所有这些仪器都必须处于良好的状态，以避免延误。 目前用于快速蒸发合成和色谱纯化后样品的快速蒸发器已被广泛使用了十多年。 该装置需要更换，因为它最近被诊断出有不可修复的缺陷。 它以每3个月需要重新填充一次的速度泄漏制冷剂气体。 这种情况代价高昂，而且在环境上是不可接受的。 为了保持该设施的生产力，并避免我们与几位生物科学家正在进行的药物化学合作的任何延误，我们要求资助购买一台新的快速蒸发器。在我们的设施中已经确定了非常有前途的抗癌先导化合物，这种新的蒸发器将允许无延迟地连续生成改进的文库和类似物。

Progress in chemical biology and medicinal chemistry relies extensively on the availability and rapid access to novel small molecules of high purity. In response to these demands, modern techniques such as combinatorial chemistry and microwave chemistry have been developed in order to accelerate and facilitate the purification of novel organic compounds. In 2004, our Department created a dedicated laboratory for combinatorial synthesis. This modern laboratory supports researchers in chemical biology and medicinal chemistry. To produce large collections of small molecules, this facility requires a chain of instrumentation, all of which must be in good order in order to avoid delays. The current rapid evaporator employed to quickly evaporate samples after synthesis and chromatographic purification has been used extensively for more than ten years. This unit needs replacement as it was recently diagnosed with a non-repairable defect. It leaks refrigerant gas at a rate requiring refills every 3 months. This situation is costly and environmentally unacceptable. To maintain the facility's productivity and avoid any delays in our ongoing medicinal chemistry collaborations with several biological scientists, we request funding for the purchase of a new rapid evaporator. Very promising anti-cancer lead compounds have been identified in our facility, and this new evaporator will allow the continuous generation of improved libraries and analogues with no delays.