A cost and environmentally effective rapid evaporator as a key component of a combinatorial synthesis facility for the generation of new types of bioactive small molecules.

点击翻译按钮获取中文摘要

Progress in chemical biology and medicinal chemistry relies extensively on the availability and rapid access to novel small molecules of high purity. In response to these demands, modern techniques such as combinatorial chemistry and microwave chemistry have been developed in order to accelerate and facilitate the purification of novel organic compounds. In 2004, our Department created a dedicated laboratory for combinatorial synthesis. This modern laboratory supports researchers in chemical biology and medicinal chemistry. To produce large collections of small molecules, this facility requires a chain of instrumentation, all of which must be in good order in order to avoid delays. The current rapid evaporator employed to quickly evaporate samples after synthesis and chromatographic purification has been used extensively for more than ten years. This unit needs replacement as it was recently diagnosed with a non-repairable defect. It leaks refrigerant gas at a rate requiring refills every 3 months. This situation is costly and environmentally unacceptable. To maintain the facility's productivity and avoid any delays in our ongoing medicinal chemistry collaborations with several biological scientists, we request funding for the purchase of a new rapid evaporator. Very promising anti-cancer lead compounds have been identified in our facility, and this new evaporator will allow the continuous generation of improved libraries and analogues with no delays.