Synthesis of glycomimetics and gycodendrimers of biological interests

具有生物学意义的糖模拟物和糖树大分子的合成

• 批准号: 1589-2008
• 负责人: Roy, René
• 金额: $ 6.41万
• 依托单位: Université du Québec à Montréal
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=449292
• 关键词: Synthesis; glycomimetics; gycodendrimers; biological; interests

Antibiotic resistance to bacterial infections is a major concern to health care systems. Hence new and alternative strategies to fight diseases are required and amongst these, prophylactic methods such as vaccinations have been extremely successful. Important infectious diseases like pneumonia, tuberculosis, and meningitis have been eradicated in developed countries due to massive vaccination programs. In this regard, our group has previously contributed to the commercialization of two such vaccines. We are proposing herein two novel and promising approaches aimed at preventing the early stage of infections by a) blocking bacteria from attaching and colonizing host tissues by virtue of their carbohydrate binding proteins present at the tip of their pilli and b) by stopping the assembly of these pilli using new therapies called pilicides. The likelihood of developing resistance is therefore greatly reduced since bacteria cannot mutate their carbohydrate receptors without impeding their attachment processes.

细菌感染的抗生素耐药性是卫生保健系统的主要问题。因此，需要新的和替代的战略来对抗疾病，其中，预防方法如疫苗接种非常成功。由于大规模的疫苗接种计划，发达国家已经根除了肺炎、结核病和脑膜炎等重要传染病。在这方面，我们小组以前曾为两种此类疫苗的商业化作出贡献。我们在此提出了两种新的和有希望的方法，其目的在于通过a）借助存在于细菌菌毛尖端的碳水化合物结合蛋白阻断细菌附着和定殖宿主组织，和B）通过使用称为杀菌毛剂的新疗法停止这些菌毛的组装来预防感染的早期阶段。因此，产生耐药性的可能性大大降低，因为细菌不能在不阻碍其附着过程的情况下突变其碳水化合物受体。