Synthesis of Glycomimetics and Gycodendrimers of Biological Interests
具有生物学意义的糖模拟物和糖树大分子的合成
基本信息
- 批准号:1589-2013
- 负责人:
- 金额:$ 3.21万
- 依托单位:
- 依托单位国家:加拿大
- 项目类别:Discovery Grants Program - Individual
- 财政年份:2014
- 资助国家:加拿大
- 起止时间:2014-01-01 至 2015-12-31
- 项目状态:已结题
- 来源:
- 关键词:
项目摘要
Cell-surface glycoconjugates are responsible for a wide range of biological interactions at the origin of pathologies. Unfortunately, the nature of the binding interactions is weak and poorly selective. The following integrated research program is aimed at using conceptually novel strategies toward the design of high affinity and specificity carbohydrate dendritic nanomaterials for the targeting of conceptually innovative carriers against cancer, bacterial and viral infections. The concept of dendrimer design will be expanded to include two new features that have been overlooked so far. The conservative and restrictive approaches to dendrimer syntheses will be changed by using different chemical motifs between each layer, thus offering additional controls into the desired biophysical properties. This innovative "onion-peel" approach will provide much greater flexibility in the synthetic schemes leading to the novel dendrimer architectures. In addition, the above modifications will be improved by providing dendrimers harboring two different surface moieties to ensure the most efficient bacterial and cancer cell targeting. This will be particularly exemplified with two types of bacteria such as P. aeruginosa and uropathogenic E. coli involved in cystic fibrosis and pyelonephritis. To integrate bactericidal properties within the nanomaterials, we also proposed to simultaneously include antibacterial agents. As an additional level of improvement in the design of novel glycodendrimers, we also propose to use medicinal chemistry methodologies through which, much better ligands candidates will become accessible. Using the above two variables (multivalency and glycomimetic), more reliable, low valency analogs will be secured. A particular emphasis will be given to organometallic and asymmetric chemistry in order to provide access to structures with key chiral centers. Spacer length, distances, hydro/lipo-philicity will all be factors to be optimized. A novel aspect will also concentrate on the syntheses of a new family of self-assembled molecules calles glycodendrimersomes.
细胞表面糖缀合物在病理学的起源中负责广泛的生物相互作用。不幸的是,结合相互作用的性质很弱并且选择性差。以下综合研究计划旨在使用概念新颖的策略来设计高亲和力和特异性的碳水化合物树突纳米材料,以针对癌症、细菌和病毒感染的概念创新载体。树枝状聚合物设计的概念将得到扩展,包括迄今为止被忽视的两个新功能。通过在每层之间使用不同的化学基序,将改变树枝状聚合物合成的保守性和限制性方法,从而为所需的生物物理特性提供额外的控制。这种创新的“洋葱皮”方法将为合成方案提供更大的灵活性,从而产生新颖的树枝状聚合物结构。此外,上述修饰将通过提供具有两个不同表面部分的树枝状聚合物来改进,以确保最有效的细菌和癌细胞靶向。这尤其以两种类型的细菌为例,例如涉及囊性纤维化和肾盂肾炎的铜绿假单胞菌和尿路致病性大肠杆菌。为了将杀菌特性整合到纳米材料中,我们还建议同时包含抗菌剂。作为新型糖树枝状聚合物设计的进一步改进,我们还建议使用药物化学方法,通过这种方法,可以获得更好的候选配体。使用上述两个变量(多价和糖模拟物),将获得更可靠的低价类似物。将特别强调有机金属和不对称化学,以便获得具有关键手性中心的结构。间隔物长度、距离、亲水/亲油性都将是需要优化的因素。一个新颖的方面还将集中于称为糖树枝状体的新自组装分子家族的合成。
项目成果
期刊论文数量(0)
专著数量(0)
科研奖励数量(0)
会议论文数量(0)
专利数量(0)
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Roy, René其他文献
Glycodendrimers: versatile tools for nanotechnology
- DOI:
10.1590/s1984-82502013000700008 - 发表时间:
2013-01-01 - 期刊:
- 影响因子:1.3
- 作者:
Roy, René;Shiao, Tze Chieh;Rittenhouse-Olson, Kate - 通讯作者:
Rittenhouse-Olson, Kate
Roy, René的其他文献
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{{ truncateString('Roy, René', 18)}}的其他基金
Conception de glycothérapeutiques nanomoléculaires
纳米分子糖疗法的概念
- 批准号:
RGPIN-2018-05570 - 财政年份:2020
- 资助金额:
$ 3.21万 - 项目类别:
Discovery Grants Program - Individual
Synthesis of Glycomimetics and Gycodendrimers of Biological Interests
具有生物学意义的糖模拟物和糖树大分子的合成
- 批准号:
1589-2013 - 财政年份:2017
- 资助金额:
$ 3.21万 - 项目类别:
Discovery Grants Program - Individual
Dynamique de collisions nucléaires aux énergies ISAC-II et GANIL (10 à 90 MeV/nucléon)
ISAC-II 和 GANIL 核能碰撞动力学 (10 × 90 MeV/nucléon)
- 批准号:
SAPIN-2014-00029 - 财政年份:2015
- 资助金额:
$ 3.21万 - 项目类别:
Subatomic Physics Envelope - Individual
Synthesis of Glycomimetics and Gycodendrimers of Biological Interests
具有生物学意义的糖模拟物和糖树大分子的合成
- 批准号:
1589-2013 - 财政年份:2015
- 资助金额:
$ 3.21万 - 项目类别:
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"Dynamique des collisions comme sonde du terme de symétrie du noyau (S1067, ISAC)"
“Dynamique des Collins comme sonde du terme de symétrie du noyau (S1067,ISAC)”
- 批准号:
250674-2012 - 财政年份:2014
- 资助金额:
$ 3.21万 - 项目类别:
Subatomic Physics Envelope - Project
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