Elucidation of the biosynthesis of 4-hydroxy-2-alkylquinolines by pseudomonas aeruginosa

铜绿假单胞菌生物合成 4-羟基-2-烷基喹啉的阐明

• 批准号: 38364-2007
• 负责人: Lépine, François
• 金额: $ 2.19万
• 依托单位: Institut national de la recherche scientifique
• 依托单位国家: 加拿大
• 项目类别: Discovery Grants Program - Individual
• 财政年份: 2010
• 资助国家: 加拿大
• 起止时间: 2010-01-01 至 2011-12-31
• 项目状态: 已结题
• 来源: https://www.nserc-crsng.gc.ca/ase-oro/Details-Detailles_eng.asp?id=450755
• 关键词: Elucidation; biosynthesis; hydroxy; alkylquinolines; pseudomonas

In recent years it has been demonstrated that bacteria communicate with one another, in a process called « Quorum Sensing ». In this mechanism, bacteria secrete one or many signalling molecules which, when they have reched a specific concentration in the medium, bind to their corresponding regulator protein that will increase the production of the signalling compounds and will also activate other virulence genes. During the early stage of an infection, the advantage of such synchronized behaviour is to wait until the number of bacteria is sufficiently large so that the simultaneous release of virulence factor could overwhelm the host defence.

近年来，已经证明细菌在一个称为“群体感应”的过程中相互交流。在这种机制中，细菌分泌一种或多种信号分子，当它们在培养基中达到特定浓度时，与它们相应的调节蛋白结合，这将增加信号化合物的产生，并且还将激活其他毒力基因。在感染的早期阶段，这种同步行为的优点是等到细菌的数量足够大，以便同时释放的毒力因子可以压倒宿主的防御。