Vestibular Activation in Benign Paroxysmal Positional Vertigo and Superior Semicircular Canal Dehiscence

良性阵发性位置性眩晕和上半规管裂开时的前庭激活

• 批准号: nhmrc : 293801
• 负责人: Dr Swee Aw
• 金额: $ 22.69万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2004
• 资助国家: 澳大利亚
• 起止时间: 2004-01-01 至 2006-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/vestibular-activation-benign-canal-dehiscence/98363
• 关键词: Vestibular; Activation; Benign; Paroxysmal; Positional

Vestibular Activation in Benign Paroxysmal Positional Vertigo and Superior Semicircular Canal Dehiscence The aim of this project is to study the pathological activation of the vestibular system in benign paroxysmal positional vertigo and superior canal dehiscence in order to achieve an improved diagnosis in both conditions and a more effective treatment for benign paroxysmal positional vertigo. These diseases provide unique opportunities to study unilateral activation of an otherwise normal human vestibular system. Benign paroxysmal positional vertigo and its variants is prevalent, especially amongst the elderly, as a major cause of dizziness and imbalance. These conditions describe a variety of vestibular lithiasis where free-floating otoconia misplaced in a semicircular canal cause abnormal deflection of the cupula, resulting in activation of the semicircular canal in a vestibular system during changes in gravitational head position. This study endeavours to develop a scientific basis for accurate diagnosis of benign paroxysmal positional vertigo and its variants. Online real-time 3-D recording and vector analysis of the nystagmus could be adapted to a 3-D video-oculography system for a more systematic approach to diagnosis and treatment. Thus, we aim to develop and trial a suitable particle repositioning manoeuvre using a mechanical device as treatment for patients who did not respond to the clinical Epley or Semont manoeuvre. Superior semicircular canal dehiscence permits sound or pressure to abnormally activate the vestibular system. In the superior canal dehiscence study, we seek to develop a more sensitive diagnostic test. If the click-evoked 3-D VOR is due to direct activation of the otoliths, then it offers an avenue to examine otolithic function. Understanding the mechanism of unilateral activation of a normal human vestibular system is important for the development of implantable vestibular prosthesis.

良性阵发性位置性眩晕和上级半规管裂开的前庭激活本项目的目的是研究良性阵发性位置性眩晕和上级半规管裂开的前庭系统的病理激活，以提高对这两种情况的诊断和对良性阵发性位置性眩晕的更有效的治疗。这些疾病提供了独特的机会，研究单侧激活，否则正常的人类前庭系统。良性阵发性位置性眩晕及其变体是普遍存在的，尤其是在老年人中，是头晕和失衡的主要原因。这些情况描述了各种前庭结石，其中自由漂浮的耳石错置于半规管中导致壶腹异常偏转，导致在重力头位置变化期间前庭系统中半规管的激活。本研究旨在为良性阵发性位置性眩晕及其变异型的准确诊断提供科学依据。在线实时三维记录和矢量分析的眼球震颤可以适应于三维视频眼电系统的诊断和治疗的一个更系统的方法。因此，我们的目标是开发和试验一个合适的颗粒复位操作使用机械装置作为治疗的患者谁没有响应的临床Epley或Semont操作。上级半规管裂开允许声音或压力异常激活前庭系统。在上级根管裂开研究中，我们寻求开发一种更敏感的诊断试验。如果点击诱发的三维VOR是由于直接激活的耳石，那么它提供了一个途径来检查耳石功能。了解正常人前庭系统单侧激活的机制对于植入式前庭假体的研制具有重要意义。