Off-Axis Head Rotation Test of Otolith Function

耳石功能的偏轴头部旋转测试

• 批准号: nhmrc : 142604
• 负责人: Dr Swee Aw
• 金额: $ 20.07万
• 依托单位国家: 澳大利亚
• 项目类别: NHMRC Project Grants
• 财政年份: 2001
• 资助国家: 澳大利亚
• 起止时间: 2001-01-01 至 2003-12-31
• 项目状态: 已结题
• 来源: https://researchdata.edu.au/off-axis-head-otolith-function/80798
• 关键词: Off; Axis; Head; Rotation; Test

Combined linear and angular head movements are integral components of our natural head movements. The vestibular sensory apparatus in the labyrinth of the inner ear, which comprises three semicircular canals and two otoliths acts as an inertial guidance system during head motion. The vestibular sensors mediate the angular and linear vestibulo-ocular reflexive eye movements imperative to stabilise vision during the head motions. However, it is unclear how these responses to sudden linear and angular motion in three dimensions are combined and processed. Diseases of the inner ear can produce incapacitating visual and balance disturbances, yet the normal function of some of the inner ears receptors, in particular the otoliths, cannot be easily tested. Clinical evidence has shown that patients with incapacitating attacks of vertigo can have impairment of either or both the semicircular canals and the otoliths. The aim of this project is to measure quantitatively the semicircular canal-otolith response to transient, high-acceleration combined linear-angular head movements to find a reliable way to test the otolith function. Based on physiological principles and my preliminary experiment, we plan to use an off-axis head rotation procedure, a three-dimensional eye movement recordings and vector analysis technique to assess the linear and angular vestibulo-ocular reflex response from the otoliths and semicircular canals in the labyrinth. The practical significance of answers to these questions is that they will characterise the combined linear and angular vestibulo-ocular reflex responses that stabilise vision during transient head movements. It will provide us with a greater understanding of the visual disturbance that patients experienced during these kinds of head movements following vestibular disease or surgery. Measurement of the linear vestibulo-ocular reflex may also provide a diagnostic test of otolith function clinically in disease states.

组合的线性和角度头部运动是我们自然头部运动的组成部分。内耳迷路中的前庭感觉器包括三个半规管和两个耳石，在头部运动期间充当惯性引导系统。前庭传感器介导的角度和线性前庭眼反射性眼球运动的必要性，以稳定在头部运动的视觉。然而，目前还不清楚这些反应突然线性和角运动在三维的组合和处理。内耳的疾病可以产生使人丧失能力的视觉和平衡障碍，但是一些内耳感受器的正常功能，特别是耳石，不能容易地测试。临床证据表明，眩晕发作的患者可能会损害半规管和耳石中的一个或两个。本研究的目的是定量测量半规管-耳石对瞬态、高加速度线性-角向头部运动的响应，以找到一种可靠的方法来测试耳石功能。基于生理学原理和我的初步实验，我们计划使用离轴头旋转程序，三维眼动记录和矢量分析技术来评估线性和角度前庭眼反射反应的耳石和半规管在迷路。这些问题的答案的实际意义在于，它们将解释在短暂的头部运动期间稳定视觉的线性和角度前庭眼反射反应的组合。它将使我们更好地了解前庭疾病或手术后患者在这些头部运动期间所经历的视觉障碍。线性前庭眼反射的测量也可以提供临床疾病状态下耳石功能的诊断测试。