Cell signalling crosstalk in development

细胞之间的交流与人与人之间通过电话的交流没有什么不同，理想情况下，一个人说话，另一个人听。进行对话依赖于积极的参与者交换位置，轮流说和听。使用手机，信息从移动设备传输到网络中的多个信号塔，找到最快的路径到达合适的接收器。考虑到在任何一个网络和任何时间拨打的电话数量，你的电话可能会干扰别人的电话，这就是所谓的不受欢迎的串扰。细胞与细胞之间的通信具有可比性，细胞具有多个网络，每个网络都是由许多蛋白质成分组成的信号通路，以分子信号的形式接收和传递信息。与手机通信不同，细胞具有相互连接的网络，允许理想的串扰，连接许多途径，并提供一种机制，可以根据条件精细地调整原始信号和细胞的反应。然而，当不受欢迎的串扰破坏了平衡，原始信号被误解时，对细胞有益的东西可能会变成灾难性的。当一个信号通路接受错误的信号进入网络，或者在错误的时间接受正确的信号时，就会出现这种情况。当信号通路被来自多个通路的串扰淹没时，也会发生这种情况。这种错误的信息削弱了整个信号网络的完整性。对于一个细胞来说，最终的结果是正常回路的崩溃，这将带来可怕的后果，因为现在存在无法控制的“喋喋不休”，无法将适当的信号“传递”给下一个玩家。我的主要目标是了解信号通路如何破译和调节汇聚在它们上的串扰，从而在消除不良信号的同时允许正确的分子信息流发生。阐明细胞在胚胎发育过程中利用串音调节信号通路的机制是非常重要的，因为非典型的、不必要的和经常过剩的串音后来与疾病相关，包括但不限于癌症、肾脏疾病、骨质疏松症和精神分裂症。

Communication between cells is no different than that between individuals over a phone, where ideally one speaks and the other listens. Carrying a conversation relies on active participants that trade places, taking turns speaking and listening. With cell phones, information travels from the mobile device to a number of towers in a network, finding the quickest route to the appropriate receiver. Given the number of calls made in any one network and at any one time, there is a chance your call may disrupt someone else's in what is called undesirable crosstalk. Cell-cell communication is comparable and cells have multiple networks each a signaling pathway composed of numerous protein components that receive and pass on information in the form of molecular signals to and from the nucleus. Unlike cell phone communication, cells have networks that are interconnected and allow for desirable crosstalk, linking many pathways and providing a mechanism that finely tunes the original signal and the cell's response depending on the conditions. What starts out as beneficial to a cell, however, can turn disastrous when undesirable crosstalk upsets the balance and the original signal gets misinterpreted. This is the case when one signaling pathway accepts the wrong signal into the network, or accepts the right one, but at the wrong time. This also happens when a signaling pathway is flooded with crosstalk from multiple pathways. This mis-information weakens the integrity of the entire signaling network. For a cell, the end result is the breakdown in the normal circuitry, which has dire consequences as there is now uncontrollable "chatter" and no way to "hand-off" the appropriate signal to the next player. My major objective is to understand how signaling pathways decipher and regulate the crosstalk converging on them, allowing for the correct flow of molecular information to occur while quenching undesirable signaling. Elucidating the mechanisms by which cells use crosstalk to modulate signaling pathways during embryonic development is of great importance as atypical, unnecessary and often surplus crosstalk is correlated later to disease conditions including, but not limited to cancer, kidney disease, osteoporosis and Schizophrenia.