Cell signalling crosstalk in development

细胞之间的交流与个人之间通过电话进行的交流没有什么不同，理想情况下，一个人说话，另一个人听。 进行对话依赖于积极的参与者，他们交换位置，轮流说话和倾听。 使用手机，信息从移动终端传输到网络中的多个发射塔，找到到达相应接收器的最快路径。 考虑到在任何一个网络中和任何一个时间进行的呼叫数量，您的呼叫可能会干扰其他人的呼叫，这就是所谓的不良串扰。细胞与细胞之间的通讯是相似的，细胞有多个网络，每个网络都是由许多蛋白质成分组成的信号通路，这些蛋白质成分以分子信号的形式向细胞核接收和传递信息。 与手机通信不同，细胞具有互连的网络，并允许理想的串扰，连接许多路径，并提供一种机制，根据条件微调原始信号和细胞的响应。然而，当不受欢迎的串扰破坏了平衡，原始信号被误解时，对细胞有益的东西可能会变成灾难性的。 这是当一个信令路径接受错误的信号进入网络，或接受正确的信号，但在错误的时间。当信号通路被来自多个通路的串扰淹没时，也会发生这种情况。这种错误信息会削弱整个信令网络的完整性。对于一个细胞来说，最终的结果是正常电路的崩溃，这会产生可怕的后果，因为现在存在无法控制的“喋喋不休”，并且没有办法将适当的信号“传递”给下一个玩家。 我的主要目标是了解信号通路如何破译和调节聚集在它们身上的串扰，允许分子信息的正确流动发生，同时淬灭不需要的信号。 阐明细胞在胚胎发育期间使用串扰来调节信号传导途径的机制是非常重要的，因为非典型的、不必要的和经常过剩的串扰后来与疾病状况相关，包括但不限于癌症、肾病、骨质疏松症和精神分裂症。

Communication between cells is no different than that between individuals over a phone, where ideally one speaks and the other listens. Carrying a conversation relies on active participants that trade places, taking turns speaking and listening. With cell phones, information travels from the mobile device to a number of towers in a network, finding the quickest route to the appropriate receiver. Given the number of calls made in any one network and at any one time, there is a chance your call may disrupt someone else's in what is called undesirable crosstalk. Cell-cell communication is comparable and cells have multiple networks each a signaling pathway composed of numerous protein components that receive and pass on information in the form of molecular signals to and from the nucleus. Unlike cell phone communication, cells have networks that are interconnected and allow for desirable crosstalk, linking many pathways and providing a mechanism that finely tunes the original signal and the cell's response depending on the conditions. What starts out as beneficial to a cell, however, can turn disastrous when undesirable crosstalk upsets the balance and the original signal gets misinterpreted. This is the case when one signaling pathway accepts the wrong signal into the network, or accepts the right one, but at the wrong time. This also happens when a signaling pathway is flooded with crosstalk from multiple pathways. This mis-information weakens the integrity of the entire signaling network. For a cell, the end result is the breakdown in the normal circuitry, which has dire consequences as there is now uncontrollable "chatter" and no way to "hand-off" the appropriate signal to the next player. My major objective is to understand how signaling pathways decipher and regulate the crosstalk converging on them, allowing for the correct flow of molecular information to occur while quenching undesirable signaling. Elucidating the mechanisms by which cells use crosstalk to modulate signaling pathways during embryonic development is of great importance as atypical, unnecessary and often surplus crosstalk is correlated later to disease conditions including, but not limited to cancer, kidney disease, osteoporosis and Schizophrenia.